Browsing by Author "Singh, Priti"

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    CHAPTER 9: Nanomaterial-Blood Interactions: A Biomedical Perspective
    (Royal Society of Chemistry, 2019) Singh, Priti; Singh, Sunil Kumar
    Within the short span of a decade, nanotechnology has gained tremendous recognition in diagnostic and therapeutic applications owing to its unique physiochemical properties. Whenever nanomaterials (NMs) are intravenously injected inside the biological system, NMs encounter the complex physiological environment of blood. Blood is a connective tissue consisting of blood cells, plasma proteins and lipoproteins, and a coagulation system that maintains the haemostasis of the body. NMs can interact with blood constituents and trigger patho-physiological events such as complement activation and thrombosis. Therefore, in this chapter, the roles of blood constituents in a biological system and interactions between NMs and blood components is critically reviewed. The shape, size, functionalisation and surface charge of NMs may be deciding factors for their adverse toxic effects. A critical analysis of nanomaterial-blood interactions will help with designing engineered NMs and manipulating their properties for impeccable applications in nanomedicine. © The Royal Society of Chemistry 2019.
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    Mesoporous nanosilica: A thromboprotective nanomaterial for biomedical applications
    (Elsevier Ltd, 2022-06-17T00:00:00) Singh, Priti; Srivastava, Sameer; Singh, Sunil Kumar
    Nanosilica is widely employed in various biomedical applications because of their tailorable physiochemical properties and excellent biocompatibility. In the present study, we have evaluated interaction of nanosilica with important coagulation components, such as platelets, a highly sensitive cell found in the blood, and coagulation proteins. Mesoporous silica nanoparticles (MSNs) were prepared using sol-gel process and characterized by FESEM and TEM to find out the size and shape of the particles. Different platelet functional parameters including platelet adhesion, aggregation, activation, secretion, clot formation and clot retraction-based studies have been carried out to investigate the impact of synthesized nanosilica on the blood coagulation system. Besides, ROS generation and increase in intracellular calcium was also monitored as they play a pivotal role in regulating platelet functions. The complete detailed study revealed that MSNs neither has stimulatory action towards platelets nor do they show any effective interaction with coagulation proteins. � 2022 Elsevier Ltd