Browsing by Author "Singh, Simranjit"

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    Artificial Intelligence Bringing Newer Paradigms in the Diagnosis, Treatment, and Management of Psoriasis
    (Springer, 2023-10-04T00:00:00) Sharma, Ravi Kant; Sharma, Manu Rashmi; Mahendra, Aneet; Sharma, Ujjawal; Singh, Simranjit; Ramniwas, Seema; Sharma, Anil Kumar
    Purpose of Review: As we know, psoriasis is the most prevalent chronic inflammatory skin condition due to aberrant immune response which is characterized by clearly demarcated red or pink thick raised skin plaques sometimes covered with dry thin silvery white scales, formed due to the cytokine-driven hyperproliferation of epidermal keratinocytes. The abnormal functioning of immune-inflammatory pathways can cause various systemic conditions including cardiovascular diseases, chronic renal disease, and metabolic syndrome. Recent Findings: In comparison to other dermatological conditions, psoriasis has greater impact on the mental health of patients leading to increased risk of psychiatric comorbidities such as depression and anxiety.�The Articial intellingence could automate the analysis and provide contextual relevance, enhance clinical reliability,�assist the clinicians in communicating objectively, minimize human fatigue related errors, decrease mortality rates,�save medical expenditures and help in easy and early diagnosis of diseases including psoriasis. Summary: Therefore, development of better approaches for the diagnosis of psoriasis and determination of its classification type and severity are necessary for disease control and management and are the need of the hour. The artificial intelligence (AI) applications in medicine and healthcare are recently emerging due to advanced computing technologies and availability of abundant data on a variety of diseases including psoriasis. Hence, AI will certainly be a boon for the early detection and management of psoriasis patients necessitating further research in this area. � 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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    Efficacy of p-coumaric acid in chronic constriction injury induced neuropathic pain in rats
    (Indian Drug Manufacturers' Association, 2021-12-14T00:00:00) Bharti, Akash; Kaur, Jaspreet; Kumar, Amit; Singh, Simranjit; Kumar, Deepak
    The present research work has been designed to evaluate the effect of p-coumaric acid in chronic constriction injury (CCI) of sciatic nerve induced neuropathic pain in rats. In addition, biochemical tests such as thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and total protein were performed in sciatic nerve tissue sample. The neuropathic pain has been effi ciently and successfully induced in rat by the performance of CCI. The battery of behavioural test showed the development of neuropathic pain as an index of rising the paw and tail thermal and mechanical pain sensitivity. The treatment of p-coumaric acid at dose 50 and 100 mg kg-1, p.o. for 15 consecutive days have been shown to produce signifi cant ameliorative effect on CCI of sciatic nerve induced neuropathic pain sensitivity. In addition, CCI of sciatic nerve also induces the oxidative stress in nervous system by rising TBARS, decrease GSH and proteins levels in sciatic nerve tissue and these effects are reversed via administration of p-coumaric acid and statistically equivalent to standard drug. Hence, it may be concluded that, p-coumaric acid can be useful in the management of neuropathic pain symptoms. � 2021 Indian Drug Manufacturers' Association. All rights reserved.