Browsing by Author "Vijayan, Veena"

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    Dihydropyrimidinone scaffold and potential therapeutic targets
    (Elsevier, 2023-08-25T00:00:00) Kumar, Adarsh; Singh, Ankit Kumar; Vijayan, Veena; Singh, Harshwardhan; Verma, Amita; Kumar, Pradeep
    Dihydropyrimidine is the most important heterocyclic ring system involved in the synthesis of RNA and DNA. Dihydropyrimidines were produced synthetically by multicomponent reactions such as the Biginelli reaction. Because of their remarkable biological characteristics, dihydropyrimidinones (DHPMs) have drawn considerable attention in recent years. In this chapter, we have described the synthetic and pharmacological properties of DHPMs employing multicomponent synthesis. It emphasizes also widespread pharmaceutical applications of DHPMs, including antitubercular, antifilarial, antihypertensive, antiinflammatory, anticancer, antifungal, antibacterial, anti-HIV, antihyperglycemic, anti-SARS, analgesic, antioxidant, anticonvulsant, anti-Alzheimer�s and antihepatitis properties. This chapter will be of immense importance for the scientists working in this area. � 2023 Elsevier Inc. All rights reserved.
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    Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective
    (MDPI, 2023-02-15T00:00:00) Kumar, Adarsh; Singh, Ankit Kumar; Singh, Harshwardhan; Vijayan, Veena; Kumar, Deepak; Naik, Jashwanth; Thareja, Suresh; Yadav, Jagat Pal; Pathak, Prateek; Grishina, Maria; Verma, Amita; Khalilullah, Habibullah; Jaremko, Mariusz; Emwas, Abdul-Hamid; Kumar, Pradeep
    Cancer is one of the major healthcare challenges across the globe. Several anticancer drugs are available on the market but they either lack specificity or have poor safety, severe side effects, and suffer from resistance. So, there is a dire need to develop safer and target-specific anticancer drugs. More than 85% of all physiologically active pharmaceuticals are heterocycles or contain at least one heteroatom. Nitrogen heterocycles constituting the most common heterocyclic framework. In this study, we have compiled the FDA approved heterocyclic drugs with nitrogen atoms and their pharmacological properties. Moreover, we have reported nitrogen containing heterocycles, including pyrimidine, quinolone, carbazole, pyridine, imidazole, benzimidazole, triazole, ?-lactam, indole, pyrazole, quinazoline, quinoxaline, isatin, pyrrolo-benzodiazepines, and pyrido[2,3-d]pyrimidines, which are used in the treatment of different types of cancer, concurrently covering the biochemical mechanisms of action and cellular targets. � 2023 by the authors.