Browsing by Author "Yadav, Rakhi"

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Impact of noncoding RNAs on cancer directed immune therapies: Now then and forever
    (John Wiley and Sons Inc, 2022-04-30T00:00:00) Roy, Roshan Kumar; Yadav, Rakhi; Sharma, Uttam; Wasson, Mishi Kaushal; Sharma, Ashok; Tanwar, Pranay; Jain, Aklank; Prakash, Hridayesh
    Accumulating evidence demonstrates that the host genome's epigenetic modifications are essential for living organisms to adapt to extreme conditions. DNA methylation, covalent modifications of histone and interassociation of noncoding RNAs facilitate the cellular manifestation of epigenetic changes in the genome. Out of various factors involved in the epigenetic programming of the host, noncoding RNAs (ncRNAs) such as microRNA (miRNA), long noncoding RNA (lncRNA), circular RNA, snoRNA and piRNA are new generation noncoding molecules that influence a variety of cellular processes like immunity, cellular differentiation and tumor development. During tumor development, temporal changes in miRNA/lncRNA rheostat influence sterile inflammatory responses accompanied by the changes in the carcinogenic signaling in the host. At the cellular level, this is manifested by the upregulation of inflammasome and inflammatory pathways, which promotes cancer-related inflammation. Given this, we discuss the potential of lncRNAs, miRNAs, circular RNA, snoRNA and piRNA in regulating inflammation and tumor development in the host. � 2022 UICC.
  • No Thumbnail Available
    Item
    Yin and yang of immunological memory in controlling infections: Overriding self defence mechanisms
    (Taylor and Francis Ltd., 2021-04-19T00:00:00) Roy, Roshan Kumar; Yadav, Rakhi; Jain, Aklank; Tripathi, Vishwas; Jain, Manju; Singh, Sandhya; Prakash, Hridayesh
    Immunological memory is critical for host immunity and decisive for individual to respond exponentially to previously encountered infection. Both T and B cell memory are known to orchestrate immunological memory with their central and effector memory arms contributing in prolonged immunity/defence mechanisms of host. While central memory helps in maintaining prolonged immunity for a particular infection, effector memory helps in keeping local/seasonal infection in control. In addition to this, generation of long-lived plasma cells is pivotal for generating neutralizing antibodies which can enhance recall and B cell memory to control re-infection. In view of this, scaling up memory response is one of the major objectives for the expected outcome of vaccination. In this line, this review deals with the significance of memory cells, molecular pathways of their development, maintenance, epigenetic regulation and negative regulation in various infections. We have also highlighted the significance of both T and B cell memory responses in the vaccination approaches against range of infections which is not fully explored so far. Highlights Pathogens induce IL-10R, PD-1, T-reg; and downregulate IL7R and IL15R for hijacking memory response IL-7, 15, Tcf-1 (Wnt5/7A), and CD28 signaling is decisive for TCM/TEM and TRM recall. Bach2 expression suppress Bim and Puma and promotes memory B cell activities VCAM1, IFN-?, and GM-CSF pathways are critical for local activation of memory cells Multi-epitope vaccines/adjuvants are potent for inducing specific memory response. � 2021 Taylor & Francis Group, LLC.