Department Of Pharmacology

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http://10.2.3.109/handle/32116/108

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Browsing Department Of Pharmacology by Subject "14?-demethylase"

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    In silico Studies of Plant-Derived Bioactive Compounds of Wedelia Species
    (Bentham Science Publishers, 2022-05-19T00:00:00) Rani, Nidhi; Dahiya, Randhir S.; Kumar, Praveen
    Background: In India, several types of plants have been researched for the treatment of various ailments. Wedelia species, belonging to the Asteraceae family, is one of the wonder plants that has been utilised in Unani, Ayurvedic, and Homeopathic treatment for a long time. Objective: The components of Wedelia species were investigated in order to create novel powerful anti-fungal drugs with low toxicity and high efficacy followed by high bioavailability. Methods: Molergo Virtual Docker was used to test the chemical components of the plant for antifungal potential against the enzyme 14-demethylase. Results: According to the findings, about fifteen compounds were identified as promising compounds with a high dock score and number of interactions. Conclusion: These compounds can further be isolated and worked upon for future research. � 2022 Bentham Science Publishers.
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    In Silico Study of the Structural Disruption of 14?-demethylase Induced by the Binding of Terminalia chebula Constituents
    (Bentham Science Publishers, 2023-07-11T00:00:00) Rani, Nidhi; Singh, Randhir; Kumar, Praveen; Verma, Nitin
    Background: Since ancient times, medicinal plants have been in use in medicine and daily life. Objective: To develop new antifungal compounds with low toxicity and high efficacy followed by high bioavailability, the constituents of Terminalia chebula were studied. Methods: The chemical constituents of the plant were evaluated for antifungal potential via Molergo Virtual Docker against the enzyme 14?-demethylase. Results: The study depicted that tannins exhibited very good potential against the enzyme and could be used further for lead development. Conclusion: The study revealed that the plant possessed various constituents with potential antifungal properties and low toxicity. � 2024 Bentham Science Publishers.