Biochemistry And Microbial Sciences - Research Publications

Permanent URI for this collectionhttps://kr.cup.edu.in/handle/32116/27

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Author: search.filters.author.Chhabra, RavindreshSubject: search.filters.subject.m5C

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    Emerging role of mRNA methylation in regulating the hallmarks of cancer
    (Elsevier B.V., 2022-10-13T00:00:00) Sarraf, Gargi; Chhabra, Ravindresh
    The dynamic chemical modifications of DNA, RNA, and proteins can transform normal cells into malignant ones. While the DNA and protein modifications in cancer have been described extensively in the literature, there are fewer reports about the role of RNA modifications in cancer. There are over 100 forms of RNA modifications and one of these, mRNA methylation, plays a critical role in the malignant properties of the cells. mRNA methylation is a reversible modification responsible for regulating protein expression at the post-transcriptional level. Despite being discovered in the 1970s, a complete understanding of the different proteins involved and the mechanism behind mRNA methylation remains largely unknown. However, these mRNA methylations have been shown to foster cancer hallmarks via specific cellular targets inside the cell. In this review, we provide a brief overview of mRNA methylation and its emerging role in regulating the various hallmarks of cancer. � 2022 Elsevier B.V. and Soci�t� Fran�aise de Biochimie et Biologie Mol�culaire (SFBBM)
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    The Epigenetics of Noncoding RNA
    (Elsevier, 2022-09-16T00:00:00) Chhabra, Ravindresh
    DNA, RNA, and the proteins are the major players in the flow of genetic information. Out of these, RNA is the most versatile biomolecule as it exists in multiple forms and each form carries out specified functions in the cell. RNA can be classified into coding and noncoding RNA (ncRNA). The noncoding RNA is further subdivided into long noncoding RNA (>200 nucleotides) and small noncoding RNA (<200 nucleotides). The coding RNA is the one which gets translated into proteins; whereas, the ncRNA is usually responsible for the regulation of gene expression. The ncRNA has been implicated in a number of pathological conditions including cancer, diabetes, neurological disorders and developmental defects. The interplay between ncRNAs and epigenetics often plays a significant role in the onset and progression of some of the aforementioned diseases. This chapter elaborates on the different ways in which epigenetic phenomenon is regulated by ncRNA and the effect of epigenetic modification on the expression of ncRNA. � 2023 Elsevier Inc. All rights reserved.