Biochemistry And Microbial Sciences - Master Dissertation

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Extraction And Identification Of Secondary Metabolites Produced By Soil Actinomycetes And Their Biochemical Characterization
(Central University of Punjab, 2018) Singh, Jahnavi Kumari; Kushawaha, Pramod
The worldwide use of antibiotics has rapidly increased since the discovery of penicillin in 1928 by Alexander Fleming, for treating terrible bacterial diseases. But in due course of time, over-consumption of antibiotics has led to an enormous selective pressure on bacteria, which has forced them to adapt to the antibiotics and hence gain development of resistance. In the past years, the excessive use of antibiotics has led to significant evolution in microorganisms where naturally occurring genes resistant to the antibiotic have been spreading fast, thus, the need for new antibiotics has increased. In the stated work, samples were collected from the mountainous sites of Himachal Pradesh and were analyzed for the presence of secondary metabolites. The bacterial species were characterized by biochemical tests and metabolites produced by them were identified.