Human Genetics And Molecular Medicine - Master Dissertation

Permanent URI for this collectionhttps://kr.cup.edu.in/handle/32116/104

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Evaluation Of Association Of Folic Acid Metabolism In Chronic Obstructive Pulmonary Disease
(Central University of Punjab, 2018) Chaudhary, Deepti; Senapati, Sabyasachi
COPD is characterized by increasing breathlessness. It is the fourth cause of death in the world and it is currently presenting a major global public health challenge, causing premature death from pathophysiological complications. It continues to be an important cause of morbidity, mortality, and health-care costs worldwide. It is a global health issue, with cigarette smoking being an important risk factor universally with several other factors, such as exposure to indoor and outdoor air pollution, occupational hazards, and infections. As the global population ages, the burden of COPD will increase in years to come. Folic acid or vitamin B9 is a water soluble vitamin plays a major role in metabolism. Since, COPD is a disease characterized by complex nutritional abnormalities and lower level of vitamin B9 and B12. Homocysteine or total homocysteine is a sulfur containing amino acid, acts as an intermediate in the metabolism of methionine in the folic acid or folate pathway. As observed among general population hyperhomocysteinaemia (mild to moderate), is mainly associated with vitamin B deficiencies, which are considered to be essential cofactors for the level and catabolism of hcy. Assessment of level of micronutrients is useful in establishing effects in COPD.
Meta-analysis and estimation of gene expression to establish the role of SFTPD in COPD
(Central University of Punjab, 2018) Nandy, Debparna; Senapati, Sabyasachi
COPD is considered to be third leading cause of death by 2020. So far, there is no proper biomarker available for the diagnosis of all the different sub-phenotypes. Multiple GWAS studies have reported the role of SFTPD (both genetic and serum protein) as a diagnosis biomarker. This current study aims to systemic - review and meta-analyse the association of anthropometric parameter (Smoking status, gender), Protein biomarker (serum SFTPD) and genetic biomarker (SFTPD rs721917) with COPD and its other phenotypes. To support the secondary findings, this study also aims to analyse the expression of SFTPD gene among COPD cases and healthy control from North Indian population. So far bronchodilators therapy are available for providing temporary relief to the patients. But bronchodilators are found to be associated with multiple number of side-effects. Indian Traditional medicine options like Ayurveda and yoga has lot to offer in this case. Many local Indian herbs are found to be significantly effective against COPD condition. Most importantly this herbs don't have any side effects. Pranayama and Dhyana have also been found to be improving Lung functions in multiple studies.