Chemistry - Research Publications

Permanent URI for this collectionhttps://kr.cup.edu.in/handle/32116/37

Browse

Filter results by typing the first few letters
Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Copper-Catalyzed C(sp3)? Functionalization and Annulation of 2-Bromoaryl Oximes with Active Methylene Compounds towards Synthesis of Isoquinoline N-Oxides
    (John Wiley and Sons Inc, 2023-06-09T00:00:00) Patel, Chandresh K.; Gujjarappa, Raghuram; Kant, Kamal; Ghanta, Susanta; Singh, Virender; Kabi, Arup K.; Al-Zaqri, Nabil; Malakar, Chandi C.
    The established process proceeds through copper (II)-catalyzed C(sp3)? functionalization of ?-diketones/?-ketoesters with 2-bromobenzaldehyde oximes followed by the intramolecular cyclization of in situ generated acylated intermediates to deliver isoquinoline N-oxides. The copper(II) acetate catalyzed C?H functionalization showed maximum efficacy at 60 �C in methanol/toluene as solvent. The described reaction conditions were applicable over a wide range of substrates with a variety of functional groups to yield isoquinoline N-oxides in yields up to 85%. The developed approach was further elucidated by means of control experiments and DFT calculations. � 2023 Wiley-VCH GmbH.
  • No Thumbnail Available
    Item
    Metal- and Hazardous Reagent-Free Transamidation Process: the NH2OH?HCl Promoted N-Formylation and N-Acylation Reaction under Solvent-Less Conditions
    (Taylor and Francis Ltd., 2023-09-14T00:00:00) Devi, Elangbam Pinky; Kant, Kamal; Kaldhi, Dhananjaya; Ghanta, Susanta; Sengupta, Ragini; Al-Zaqri, Nabil; Singh, Virender; Malakar, Chandi C.
    An efficient transamidation process has been described under solvent-less conditions. The transformation has been accomplished by employing NH2OH?HCl as a reagent and amines as substrates. The developed method is achieved in the absence of metals and hazardous reagents. A series of amines were explored to obtain the N-formylation and N-acylation reactions with excellent yields (81-96%) of products. The DFT analysis was also performed, which provides a clear understanding of the described N-formylation process. The postulated mechanism is well supported by the control experiments. � 2023 Taylor & Francis Group, LLC.
  • No Thumbnail Available
    Item
    Synthesis and Characterization of Novel Pd@rGO?CuFe2O4 Magnetic Nanoparticles: A Recyclable Catalyst for C?C Coupling Reaction in Biomass-Derived Organic Solvent
    (John Wiley and Sons Inc, 2023-10-06T00:00:00) Teli, Yaqoob A.; Reetu, Reetu; Singh, Priyanka Gurdev; Patel, Mayur Jagdishbhai; Dash, Sonali; Paine, Snehangshu; Prabhakar, Poornachandra Shamanna; Singh, Virender; Keremane, Kavya S.; Al-Zaqri, Nabil; Mukherjee, Kalisadhan; Dutta, Saikat; Malakar, Chandi C.
    Development of new, cost effective, stable heterogeneous catalyst for the organic transformations is an important thematic area of research. Present work describes the development of new Pd@rGO?CuFe2O4 catalyst and demonstrates its effectiveness for Suzuki-Miyaura type coupling reactions. The additional advantage of this reaction is its feasibility using biomass-derived solvent like ?-Valerolactone (GVL) in aqueous media. The catalyst is prepared hydrothermally and characterized using XRD, FESEM, EDX, and XPS analysis. The catalyst exhibits excellent activity and recyclability (up to six times) in the C?C coupling reaction to deliver the corresponding biaryl molecules in yields up to 90 %. High efficiency for the conversion of nitriles to amides is also revealed by the prepared catalyst. � 2023 Wiley-VCH GmbH.