Pharmacology - Research Publications

Permanent URI for this collectionhttps://kr.cup.edu.in/handle/32116/111

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Author: search.filters.author.Bijalwan, Anjali

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    Neuroprotective potential of Moringa oleifera mediated by NF-kB/Nrf2/HO-1 signaling pathway: A review
    (John Wiley and Sons Inc, 2022-10-07T00:00:00) Mundkar, Maroti; Bijalwan, Anjali; Soni, Divya; Kumar, Puneet
    Moringa oleifera is a traditional Indian herb belonging to the Moringaceae family, it is commonly known as the horse-radish tree, drumstick, or sahajna. In developing countries, Moringa is used as feed for both humans and animals due to its well-known antioxidant, anti-inflammatory, and anti-apoptotic properties owing to its several phytoconstituents including ?-carotene, quercetin, kaempferol, ascorbic acid, flavonoids, phenolic acid, rhamnose, glycosylates, glucomoringin, and isothiocyanates. These constituents help to maintain the brain antioxidant enzyme levels, mitochondrial functions, and neurogenesis, showing neuroprotective effects in several neurodegenerative disorders including Parkinson's Disease, Alzheimer's Disease, Huntington's Disease, and Amyotrophic lateral sclerosis. This review discusses various phytoconstituent of moringa and their therapeutic potential in various neurological disorders. Additionally, we also concise the safety and toxicity profile, of different molecular pathways involved in the neuroprotective effect of M. oleifera including M. oleifera nanoparticles for better therapeutic value. Practical applications: Several clinical and preclinical studies on Moringa oleifera have been conducted, and the outcomes indicate moringa could be used in the treatment of brain disorders. As a result, we conclude that moringa and its nanoformulations could be employed to treat neurological problems. In the future, M. oleifera phytoconstituents could be evaluated against specific signaling pathways, which could aid researchers in discovering their mechanism of action. Furthermore, the use of moringa as a nutraceutical owing to its myriad pharmacological potential will go a long way in boosting the economy of countries that grow moringa on a large scale. � 2022 Wiley Periodicals LLC.
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    Natural Products as an Alternative Therapy for Brain Tumors: From Bench To Bedside
    (Springer Singapore, 2022-09-28T00:00:00) Kumar, Sachin; Kumar, Mandeep; Bijalwan, Anjali; Sharma, Shubham; Kumar, Puneet
    Incremental elevation in the trends of a brain tumor in recent years accounts for 5% adult population, whereas the number exceeds 70% in the case of children. Evidence reveals an eventual metastasize of 20%-30% of malignant tumors to the brain�s different regions. Compression in the brain tissue and elevated intracranial pressure mediated by benign and malignant tumors contributed to severe consequences like the central nervous system (CNS) damage or even imperil the patient�s life. Despite multiple therapeutic strategies in the market, none of the drugs are fully effective and safe. Strategic advancement indicates chemotherapy as a treatment of choice for critical conditions like brain tumors, but the chemotherapy drugs toxicity is still a major therapeutic hurdle. Plants and their derived natural products are one of the most emerging targets to strike against brain tumors. Analogs of several natural products are already demonstrated as antitumor in nature, and day by day, advancements unfold various other plant and plant derivatives having such antitumor activity. This chapter aims to underline and emphasize the antitumor agents, which can target brain tumors procured from the natural origin such as natural products and their analogs. The available data on different plants and isolated compounds of natural origin used to reduce and arrest brain tumors is also discussed here. � Springer Nature Singapore Pte Ltd. 2022.
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    Role of vitamins and minerals as immunity boosters in COVID-19
    (Springer Science and Business Media Deutschland GmbH, 2021-06-10T00:00:00) Kumar, Puneet; Kumar, Mandeep; Bedi, Onkar; Gupta, Manisha; Kumar, Sachin; Jaiswal, Gagandeep; Rahi, Vikrant; Yedke, Narhari Gangaram; Bijalwan, Anjali; Sharma, Shubham; Jamwal, Sumit
    Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) known as coronavirus disease (COVID-19), emerged in Wuhan, China, in December 2019. On March 11, 2020, it was declared a global pandemic. As the world grapples with COVID-19 and the paucity of clinically meaningful therapies, attention has been shifted to modalities that may aid in immune system strengthening. Taking into consideration that the COVID-19 infection strongly affects the immune system via multiple inflammatory responses, pharmaceutical companies are working to develop targeted drugs and vaccines against SARS-CoV-2 COVID-19. A balanced nutritional diet may play an essential role in maintaining general wellbeing by controlling chronic infectious diseases. A balanced diet including vitamin A, B, C, D, E, and K, and some micronutrients such as zinc, sodium, potassium, calcium, chloride, and phosphorus may be beneficial in various infectious diseases. This study aimed to discuss and present recent data regarding the role of vitamins and minerals in the treatment of COVID-19. A deficiency of these vitamins and minerals in the plasma concentration may lead to a reduction in the good performance of the immune system, which is one of the constituents that lead to a poor immune state. This is a narrative review concerning the features of the COVID-19 and data related to the usage of vitamins and minerals as preventive measures to decrease the morbidity and mortality rate in patients with COVID-19. � 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG.