Pharmacology - Research Publications

Permanent URI for this collectionhttps://kr.cup.edu.in/handle/32116/111

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Author: search.filters.author.Chalotra, Rishabh

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    Treatment of diabetic complications: do flavonoids holds the keys?
    (Taylor and Francis Ltd., 2023-07-12T00:00:00) Chalotra, Rishabh; Gupta, Tanya; Chib, Shivani; Amanat, Muhammed; Kumar, Puneet; Singh, Randhir
    Diabetes mellitus (DM) is an endocrinological disorder in which blood sugar levels get elevated and if unmanaged, it leads to several critical complications. Existing therapies or drugs are not able to attain absolute control of DM. Moreover, associated side/adverse effects associated with pharmacotherapy further worsen the Quality of life of patients. Present review is focused on therapeutical potential of flavonoids in management of diabetes and diabetic complications. Plenteous literature has established significant potential of flavonoids in the treatment of diabetes and diabetic complications. A number of flavonoids are found to be effective in treatment of not only diabetes but progression of diabetic complication was also found to be attenuated with the use of flavonoids. Moreover, SAR studies of some flavonoids also indicated the that efficacy of flavonoids is increased with a change in functional group of flavonoids in the treatment of diabetes and diabetic complications. A number of clinical trials are into action to investigate the therapeutic potential of flavonoids as first-line drugs or as adjuvants for treatment of diabetes and diabetic complications. Owing to their diverse mechanism of action, efficacy and safety, flavonoids may be conscripted as potential candidate for treatment of diabetic complications. � 2023 Taylor & Francis Group, LLC.
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    Sources and Occurrence of Pharmaceuticals Residue in the Aquatic Environment
    (CRC Press, 2023-06-29T00:00:00) Chaudhary, Rishabh; Chalotra, Rishabh; Singh, Randhir
    Large amounts of pharmaceutical items are wasted or are not utilized effectively for a variety of reasons, and as a result, they wind up in the water and have an adverse effect on aquatic ecosystems, and ultimately destroy biodiversity in aquatic life. All these actions directly affect the human�s life. There are several types of pharmaceutical wastes, and their inappropriate disposal in the environment has hazardous effects on humans, animals, as well as on the ecosystem. Pharmaceutical waste enters into the environment via several routes and gets mixed into the soil and water system which affects aquatic life. There are several methods for the disposal of pharmaceutical waste into the environment which can lessen the damage produced by this pharmaceutical waste to the ecosystem. The present chapter emphasizes on the disposal of pharmaceutical waste, veterinary medicines, nuclear medicine waste; biodegradation; and the disposal of antibiotics and their effect on microorganisms in the aquatic environment. � 2024 selection and editorial matter, Vinod Kumar Garg, Ashok Pandey, Navish Kataria, and Caterina Faggio; individual chapters, the contributors.
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    Zingiber roseum Roscoe. (Zingiberaceae): Current and future perspective
    (Elsevier B.V., 2023-05-07T00:00:00) Amanat, Muhammed; Gautam, Swati; Chalotra, Rishabh; Lal, Kanhaiya; Gupta, Tanya; Agrawal, Rohini; Mojwar, Somdutt; Singh, Randhir
    Introduction: A perennial, aromatic, tuberose plant Zingiber roseum (Roscoe.) (Zingiberaceae), flourishes in tropical and subtropical climates. In Traditional Chinese Medicine, several pharmacological properties of Zingiber roseum have been reported its antiseptic, antivertigo, and antidiarrheal activities. Therefore, the present article aims to provide insights into the ethnomedicinal, phytochemistry, and pharmacology of Zingiber roseum. Methods: The literature was compelled after systematically searching scientific databases, including Scopus, PubMed, Google Scholar, and Research Gate. The selection criteria for the plant comprised the therapeutic potential of Zingiber roseum and its active components. Moreover, to explore anti-diabetic activity, ligands of interest from Z. roseum were evaluated for their affinity towards PPAR-? and PPAR-?. Results and discussions: Out of 200 articles, 140 were selected for the current study, and from the para-topic literature, it was found that Zingiber roseum has numerous pharmacological properties due to the presence of phytoconstituents like flavonoids, alkaloids, phenolic chemicals, terpenoids, saponins, and phytosterols. Furthermore, in silico studies were carried out using PyRx. It was found that rosmarinic acid (-8.3 kcal/mol) and stigmasterol (-11.12 kcal/mol) exhibited the highest binding affinities for PPAR-? and PPAR-?, respectively, when compared to standard Rosiglitazone. Conclusion: It may be concluded that Z. roseum has several therapeutic activities. Moreover, in silico studies revealed the anti-diabetic action of Z. roseum via modulation of PPAR-? and PPAR-?. � 2023 The Author(s)
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    Phyto-pharmacology of Most Common Indian Culinary Spices and their Potential in Developing New Pharmaceutical Therapies
    (Bentham Science Publishers, 2023-04-03T00:00:00) Maqbool, Mubashir; Chaudhary, Kakul; Chalotra, Rishabh; Chauhan, Samrat; Dahiya, Randhir Singh
    Background: Culinary spices and Indian kitchens share a historical relationship for centuries. An average Indian kitchen contains a lot of spices like fennel, cardamom, cumin, turmeric, clove, black pepper, etc., used to increase the aroma and taste of food. Scientific research suggested the pharmacological activities of these kitchen spices, as most of them enhance the appetite, digestion, and have anti-inflammatory and analgesic properties, and some spices are potent anticancer, antidiabetic, and anti-obesity. Some Culinary spices are unexplored scientifically. Objective: The objective of this study is to investigate the presently explored spices and some unexplored spices which might be used in certain parts of the world to enhance the flavor and could have medicinal benefits, studying their pharmacological actions in controlling or managing diseases. Methods: Numerous surveys in literature were done in response to determining the culinary spices used commonly in Indian kitchens and also some rare spices which might be used in certain parts of the world for their pharmacological, and traditional uses, their chemical constituents having pharmacological activities. Relevant peer-reviewed publications were searched through various databases such as ScienceDirect, PubMed, Google Scholar, Research Gate, etc. Results: A total of 11 common culinary spices like cumin, cardamom, cloves, etc. are studied regarding their common kitchen role, traditional uses, and their explored pharmacological activities, and 11 other spices like Alpinia galanga, Prunus mahaleb, Grain of Paradise, etc., which are used in some parts of the world having medicinal properties are also studied. The chemical constituents of these plants are also studied which could be responsible for their medicinal activity. Conclusion: In this review, an approach was made to study the common culinary spices and other culinary spices which might not be most common, having medicinal properties, so that better treatment options could be available for future generations. � 2024 Bentham Science Publishers.
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    Traditional Drugs Originating from Selected Medicinal Plants: An Intervention for Anaemia
    (Bentham Science Publishers, 2023-01-06T00:00:00) Chalotra, Rishabh; Dhanawat, Meenakshi; Maivagna, Chamasse Homary; Gupta, Sumeet
    Background: Anaemia is the most common disease that affects mostly females and children and is most prevalent in developing countries. Among various causes sickle cell anaemia is one of them, which is a cause of concern. Sickle Cell Disease (SCD) causes problems like blockage of blood flow, causing pain, and fatigue and also leads to death. Objective: With the advancement in science, diseases that were once considered unable to cure can be stopped or prevented and, in some cases, also be cured. As current therapies for the treatment of sickle cell anaemia are limited, like blood transfusions, bone marrow transfusions, etc., a non-surgical method where plant extracts or compounds were found effective in stopping, preventing, and in some cases rever-sal of SCD. In this review, we tried to gather information about those plants and compounds. Methods: Numerous surveys in the literature were performed to determine the plants which have shown their potential against SCD. Relevant peer-reviewed publications were searched through various databases such as ScienceDirect, PubMed, Google Scholar, Research Gate, etc. Results: A total of more than 50 medicinal plants such as Acacia catechu, Alchornea cordifolia, Anchomanes difformis, Khayase negalensis, Terminalia catappa, etc., have been identified based on their potential against SCD, and 15 compounds such as Butylurea, Glyceraldehyde, Potassium cya-nate, urea, etc., have also been identified which could work against SCD. These plants acting on sickle cell anemia on various pathways are also discussed. Conclusion: In this review, an approach was made to study those plants which have an effect against SCD, with proper mechanisms and compounds that show potency against this disease. So that better treatment options could be available for future generations. � 2023 Bentham Science Publishers.