Pharmacology - Research Publications
Permanent URI for this collectionhttps://kr.cup.edu.in/handle/32116/111
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Item 1,3-Oxazine as a Promising Scaffold for the Development of Biologically Active Lead Molecules(John Wiley and Sons Inc, 2023-10-16T00:00:00) Gupta, Nidhi; Saini, Vipin; Basavarajaiah, S.M.; Dar, Mohammad Ovais; Das, Rina; Dahiya, Randhir SinghHeterocyclic compounds form an important part of wide range of biologically active molecules. The heteroatom provides them specificity for various receptors. 1,3-oxazine has been considered as a privileged scaffold in many medicinal chemistry applications. Compounds having 1,3-oxazine moiety exhibit broad range of biological applications such as anticancer, antimicrobial, anti-inflammatory, antiplatelet, antitubercular and alpha-glucosidase inhibition activities. In this review, we consolidate the recent developments in the synthesis and biological activities of 1,3-oxazine containing compounds. Also, the structure activity relationship (SAR) studies of different derivatives exhibiting several biological activities are summarized. Database such as Science direct, Pubmed and Google scholar were searched using keywords �1,3-Oxazine�, �synthesis�, �derivatives�, and �biological activities�. The review would provide a lead for the development of competent candidates with 1,3-oxazine moiety having broad range of applications in the treatment of several human disorders. � 2023 Wiley-VCH GmbH.Item Phyto-pharmacology of Most Common Indian Culinary Spices and their Potential in Developing New Pharmaceutical Therapies(Bentham Science Publishers, 2023-04-03T00:00:00) Maqbool, Mubashir; Chaudhary, Kakul; Chalotra, Rishabh; Chauhan, Samrat; Dahiya, Randhir SinghBackground: Culinary spices and Indian kitchens share a historical relationship for centuries. An average Indian kitchen contains a lot of spices like fennel, cardamom, cumin, turmeric, clove, black pepper, etc., used to increase the aroma and taste of food. Scientific research suggested the pharmacological activities of these kitchen spices, as most of them enhance the appetite, digestion, and have anti-inflammatory and analgesic properties, and some spices are potent anticancer, antidiabetic, and anti-obesity. Some Culinary spices are unexplored scientifically. Objective: The objective of this study is to investigate the presently explored spices and some unexplored spices which might be used in certain parts of the world to enhance the flavor and could have medicinal benefits, studying their pharmacological actions in controlling or managing diseases. Methods: Numerous surveys in literature were done in response to determining the culinary spices used commonly in Indian kitchens and also some rare spices which might be used in certain parts of the world for their pharmacological, and traditional uses, their chemical constituents having pharmacological activities. Relevant peer-reviewed publications were searched through various databases such as ScienceDirect, PubMed, Google Scholar, Research Gate, etc. Results: A total of 11 common culinary spices like cumin, cardamom, cloves, etc. are studied regarding their common kitchen role, traditional uses, and their explored pharmacological activities, and 11 other spices like Alpinia galanga, Prunus mahaleb, Grain of Paradise, etc., which are used in some parts of the world having medicinal properties are also studied. The chemical constituents of these plants are also studied which could be responsible for their medicinal activity. Conclusion: In this review, an approach was made to study the common culinary spices and other culinary spices which might not be most common, having medicinal properties, so that better treatment options could be available for future generations. � 2024 Bentham Science Publishers.Item Blockade of protease-activated receptor 2 (PAR-2) attenuates vascular dyshomeostasis and liver dysfunction induced by dengue virus infection(Churchill Livingstone, 2022-06-27T00:00:00) Sood, Ankita; Gautam, Isha; Singh, Gaaminepreet; Joshi, Jagdish Chandra; Dahiya, Randhir Singh; Arora, SandeepThe World Health Organization (WHO) recognizes dengue infection as a major public health concern in tropical and subtropical countries. Dengue infection is recognized as the second most deadly vector-borne disease in the world, based upon its incidence and mortality rate. Vascular dyshomeostasis and liver dysfunction are the major pathological manifestations in dengue patients. Vascular events in dengue patients include dropping of pulse rate, increased capillary leakage, hypotension, life-threatening hemorrhage due to release of inflammatory cytokines, growth factors, matrix metalloproteinase (MMP). The evident increase in cytokines, chemokines, and growth factors could further induce the release of pro- inflammatory cytokines and reactive oxygen species (ROS) by activating macrophages, monocytes, and T cells resulting in endothelial dysfunction and enhanced permeability in vessels. Moreover, the anti-dengue viral protein antibodies could target clotting cascades and endothelial cells, contributing to the vascular complications. Evidence has also indicated that infiltration of NK T cells and cytotoxic CD8+ cells during the early and late phases of dengue infection results in intra-hepatic damage. Several pieces of evidence have revealed that PAR-2 activation could regulate inflammatory cytokine release, immune cell activation, and endothelial cell damage. Thus, PAR-2 activation can be associated with vascular dyshomeostasis and hepatic dysfunction during critical phases of dengue infection. In this study, we correlate the pathological manifestations of dengue infection with PAR-2 activation and generate the proof-of-concept that targeting this receptor could abrogate these changes. � 2022 Elsevier LtdItem Chemical Constituents Based Approach for the Management of Diabetes(Bentham Science Publishers, 2022-03-23T00:00:00) Sharma, Prerna; Rani, Nidhi; Gangwar, Aishwarya; Dahiya, Randhir Singh; Verma, NitinBackground: A number of complexities in compliance with long-term diabetes have been elicited. It has become a global concern without any convincing medicinal, therapeutical methodology. Both hyperglycaemia and oxidative pressure are major notable parts that play a significant role in the initialization of diabetic inconvenience. Natural medications have gained a lot of attention in recent years as expected restorative specialists in the prevention and treatment of diabetic complications due to their many objectives and less poisonous outcomes. This survey means to evaluate the accessible information on therapeutic spices for constriction and the executives of diabetic complications. Materials and Methods: Bibliographic investigation was accomplished by checking old-style course books and papers, directing overall bases of logical information (SCOPUS, PUBMED, SCIELO, Google Scholar, NISCAIR,) to recapture accessible distributed writing. For the assessment of plants with the potential in calming diabetic complications, several inclusion models rely on the numerous medicinal spices as well as their crucial mixes. Furthermore, several models, including plants, have been considered, each of which has a suitable impact on increasing oxidative pressure in diabetes. Results: Different therapeutic plants/plant withdrawals containing alkaloids, terpenoids, phenolic compounds, flavonoids, saponins, and phytosterol-type synthetic constituents were uncovered that are profitable in the administration of diabetic complexities. Results may be attributed to the improvement of oxidative pressure, constant hyperglycemia, and twitch of different metabolic pathways related to the pathogenesis of diabetic confusions. Conclusion: An optimistic approach for new medication terminology to treat diabetic confusion is screening compound competitors from homegrown medication. Investigation of the activity of different plant extracts as well as their potency profile and to determine their job in the treatment of diabetic inconveniences must be there. In addition, an ideal rat model which imitates human diabetic complications ought to be created. � 2023 Bentham Science Publishers.