Pharmacology - Research Publications

Permanent URI for this collectionhttps://kr.cup.edu.in/handle/32116/111

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Author: search.filters.author.Navik, Uma Shanker

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    Targeting Mitochondria as a Novel Disease-Modifying Therapeutic Strategy in Cancer
    (Springer Singapore, 2022-09-28T00:00:00) Bhatti, Gurjit Kaur; Pahwa, Paras; Gupta, Anshika; Sidhu, Inderpal Singh; Navik, Uma Shanker; Reddy, P. Hemachandra; Bhatti, Jasvinder Singh
    Mitochondria are essential for the metabolism of energy, regulation of apoptosis, and cell signaling. Overproduction of reactive oxidation species (ROS) in mitochondria is one of the indications of cancer cells. Moreover, this boosts the proliferation of cancerous cells by causing genomic instability and altering gene expressions. Mitochondrial and nuclear DNA mutations caused by oxidative damage impair the mechanism of oxidative phosphorylation and can lead to more mitochondrial ROS output, genome instability, and cancer development. The classic approach to target mitochondria of cancerous cells with novel targeted therapeutics helps in targeting the mitochondrial apoptotic proteins and changing energy metabolism. A key benefit of selective drug delivery is that it reduces the drug�s toxicity and increases specificity. A better understanding of the mitochondrial role in tumor growth will help design more therapeutic agents with better selectivity. � Springer Nature Singapore Pte Ltd. 2022.
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    Targeting Mitochondria as a Novel Disease-Modifying Therapeutic Strategy in Cancer
    (Springer Nature, 2022-01-31T00:00:00) Bhatti, Gurjit Kaur; Pahwa, Paras; Gupta, Anshika; Navik, Uma Shanker; Reddy, P. Hemachandra; Bhatti, Jasvinder Singh
    Mitochondria are important for the metabolism of energy, regulation of apoptosis and cell signaling. Overproduction of reactive oxidation species (ROS) in mitochondria is one of the indications of cancer cells; moreover, this boosts the proliferation of cancerous cells by causing genomic instability and altering gene expressions. Mitochondrial and nuclear DNA mutations, caused by oxidative damage which impairs the mechanism of oxidative phosphorylation, can lead to more mitochondrial ROS output, genome instability, and the development of the cancer. Classic approach to target mitochondria of cancerous cells with novel-targeted therapeutics helps in targeting the mitochondrial apoptotic proteins and changing energy metabolism. Key benefit of selective drug delivery is it reduces the toxicity of drug and increases specificity. Better understanding of mitochondrial role in tumor growth will help to design more therapeutic agents with better selectivity. � Springer Nature Singapore Pte Ltd. 2022.
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    Emerging role of non?coding RNA in health and disease
    (Springer, 2021-04-21T00:00:00) Bhatti, Gurjit Kaur; Khullar, Naina; Sidhu, Inderpal Singh; Navik, Uma Shanker; Reddy, Arubala P.; Reddy, P. Hemachandra; Bhatti, Jasvinder Singh
    Human diseases have always been a significant turf of concern since the origin of mankind. It is cardinal to know the cause, treatment, and cure for every disease condition. With the advent and advancement in technology, the molecular arena at the microscopic level to study the mechanism, progression, and therapy is more rational and authentic pave than a macroscopic approach. Non-coding RNAs (ncRNAs) have now emerged as indispensable players in the diagnosis, development, and therapeutics of every abnormality concerning physiology, pathology, genetics, epigenetics, oncology, and developmental diseases. This is a comprehensive attempt to collate all the existing and proven strategies, techniques, mechanisms of genetic disorders including Silver Russell Syndrome, Fascio- scapula humeral muscular dystrophy, cardiovascular diseases (atherosclerosis, cardiac fibrosis, hypertension, etc.), neurodegenerative diseases (Spino-cerebral ataxia type 7, Spino-cerebral ataxia type 8, Spinal muscular atrophy, Opitz-Kaveggia syndrome, etc.) cancers (cervix, breast, lung cancer, etc.), and infectious diseases (viral) studied so far. This article encompasses discovery, biogenesis, classification, and evolutionary prospects of the existence of this junk RNA along with the integrated networks involving chromatin remodelling, dosage compensation, genome imprinting, splicing regulation, post-translational regulation and proteomics. In conclusion, all the major human diseases are discussed with a facilitated technology transfer, advancements, loopholes, and tentative future research prospects have also been proposed. � 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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    Novel pharmacological approaches for diabetic complications
    (Nova Science Publishers, Inc., 2021-03-24T00:00:00) Arora, Anchal; Navik, Uma Shanker; Jaiswal, Aiswarya; Kaur, Prabhsharan; Kumar, Puneet
    Diabetes is a chronic illness characterized by uncontrolled hyperglycemia, disturbances in carbohydrate, and lipid and protein metabolism due to impaired function of insulin-secreting pancreatic ?-cell, insulin action or both. If not treated on time diabetes patients are more prone to developing secondary complications such as microvascular complications, including nephropathy, retinopathy, neuropathy, diabetic foot, dermopathy, and macrovascular complications like coronary arteries disease, peripheral arterial disease, stroke and cardiomyopathy. This increases the co-morbidity and mortality rate among diabetes patients. Therefore, hyperglycemia management could be of profound clinical significance to reduce the rate of complications of diabetes. Further, hyperglycemia results in the activation of multiple abnormal signaling pathways that poses more complex diabetes pathology resulting in end-organ damage. Traditionally, the available approved therapy, such as insulin and sulphonylureas, possesses side effects such as weight gain and hypoglycaemic shock. Therefore developing a novel therapy for targeting complex pathways for mitigating diabetes complications is highly appreciable. Hence, this chapter aims to discuss the novel therapeutic approaches for treating diabetes complications with their mechanism of action. � 2021 Nova Science Publishers, Inc.