Pharmacology - Research Publications

Permanent URI for this collectionhttps://kr.cup.edu.in/handle/32116/111

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    In Silico Study of the Structural Disruption of 14?-demethylase Induced by the Binding of Terminalia chebula Constituents
    (Bentham Science Publishers, 2023-07-11T00:00:00) Rani, Nidhi; Singh, Randhir; Kumar, Praveen; Verma, Nitin
    Background: Since ancient times, medicinal plants have been in use in medicine and daily life. Objective: To develop new antifungal compounds with low toxicity and high efficacy followed by high bioavailability, the constituents of Terminalia chebula were studied. Methods: The chemical constituents of the plant were evaluated for antifungal potential via Molergo Virtual Docker against the enzyme 14?-demethylase. Results: The study depicted that tannins exhibited very good potential against the enzyme and could be used further for lead development. Conclusion: The study revealed that the plant possessed various constituents with potential antifungal properties and low toxicity. � 2024 Bentham Science Publishers.
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    Nutrition and neurological disorders
    (Elsevier, 2023-06-16T00:00:00) Sharma, Prerna; Gangwar, Aishwarya; Rani, Nidhi; Singh, Randhir
    Nutritional intakes, homeostasis of glucose and also of electrolytes, are controlled by the central nervous system which triggers the various sensations. Certain risks are associated with malnutrition that may have severe effects and are a major cause of neurological diseases. About 792 million people from chronic food deficiencies are influenced in the whole world. Acute neurological patients may have a wide range of enhanced metabolism and catabolism seen due to long-term fasting. Acute neurological diseases include spinal cord injuries, traumatic brain injury, cancer, and cerebral vascular accident hemorrhagic or ischemic, whereas chronic neurological diseases include Parkinson's disease, several dementia's and Alzheimer's disease, and amyotrophic lateral sclerosis. Treatment options must include the nutritional evaluation periodically. Also, to rectify the nitrogen balance depletion, intake of nutrition must be enhanced and hyper alimentation must be avoided. � 2023 Elsevier Inc. All rights reserved.
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    Imidazole and Derivatives Drugs Synthesis: A Review
    (Bentham Science Publishers, 2022-11-22T00:00:00) Rani, Nidhi; Singh, Randhir; Kumar, Praveen
    Imidazoles have long held a special place in heterocyclic chemistry, and their derivatives have piqued interest in recent years due to their diverse chemistry and pharmacology fea-tures. Imidazole is a biologically and pharmaceutically important nitrogen-containing heterocy-clic ring. As a result, researchers have been interested in imidazole molecules. For a century and a half, purine, histamine, and other natural compounds all contained the imidazole ring. A number of imidazole drugs have been prepared and marketed for the treatment of various diseases. In view of this, we herein report a detailed account of synthetic procedures for various imidazole drugs. � 2023 Bentham Science Publishers.
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    Molecular docking study of asafoetida phytoconstituents as 14?-demethylase and transpeptidase inhibitors
    (Nova Science Publishers, Inc., 2022-11-24T00:00:00) Rani, Nidhi; Singh, Randhir; Agrawal, Rohini; Kaur, Rajwinder; Kumar, Praveen
    Asafoetida, an oleo gum resin obtained from Ferula asafoetida of medicinal and nutritional importance. It has been traditionally used for the treatment of various ailments as spice and medicine from centuries. A number of phytoconstituents are present in Ferula asafoetida which are responsible for pharmacological properties. To evaluate to potential of Ferula asafoetida in the treatment of microbial infections, molecular modeling technique was utilized. 74 phytoconstituents of asafoetida were created from ACD Chem sketch software and PDBs for 14?-demethylase and transpeptidase were retrieved from RCSB PDB database. Docking studies were carried out using Mol Dock score software. All the prepared ligands were evaluated for drug likeliness properties using Swiss ADME. Among 74 compounds, Asacoumarin A was found to be good inhibitor of enzymes under investigation and can be a potential lead molecule for treatment of bacterial and fungal infections. � 2023 Nova Science Publishers, Inc.
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    Diabetic Neuropathy: A Repercussion of Vitamin D Deficiency
    (Bentham Science Publishers, 2022-08-18T00:00:00) Sharma, Prerna; Rani, Nidhi; Gangwar, Aishwarya; Singh, Randhir; Kaur, Rajwinder; Upadhyaya, Kumud
    Diabetes mellitus is a crucial health issue worldwide. The worldwide ubiquity is 8.8% among adults, which is predicted to rise to 10.4% by 2040. Diabetic neuropathy is a long-term complication associated with the diabetes mellitus condition, which primarily targets Schwann cells, peripheral axons and cell bodies (perikarya) in DRG (dorsal root ganglia). It can be accom-panied by different factors such as metabolic factors such as insulin resistance, hypertension, obe-sity, low HDL level, and hypertriglyceridemia. The etiology of DPN is multifactorial. It is caused by hyperglycemia, micro-angiopathy, HbA1c, duration of diabetes, smoking status, high-density lipoprotein cholesterol and hypertension. Also, increased glucose conditions decrease vitamin D levels. Vitamin D, which is involved in neurotrophins such as NGF (nerve growth factor) and NCH (neuronal calcium homeostasis), plays a neuroprotective role in peripheral nerves. Depletionleads to vitamin D deficiency which further develops peripheral neuropathy in diabetic patients. Accu-mulation of AGEs (advanced glycation end product) plays a significant role in the pathogenesis of sensory neuronal damage. It contributes to microangiopathy and endoneurial vascular dysfunction in peripheral nerves. With vitamin D supplementation, the neuropathy pain scores were improved. � 2023 Bentham Science Publishers.
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    In silico Studies of Plant-Derived Bioactive Compounds of Wedelia Species
    (Bentham Science Publishers, 2022-05-19T00:00:00) Rani, Nidhi; Dahiya, Randhir S.; Kumar, Praveen
    Background: In India, several types of plants have been researched for the treatment of various ailments. Wedelia species, belonging to the Asteraceae family, is one of the wonder plants that has been utilised in Unani, Ayurvedic, and Homeopathic treatment for a long time. Objective: The components of Wedelia species were investigated in order to create novel powerful anti-fungal drugs with low toxicity and high efficacy followed by high bioavailability. Methods: Molergo Virtual Docker was used to test the chemical components of the plant for antifungal potential against the enzyme 14-demethylase. Results: According to the findings, about fifteen compounds were identified as promising compounds with a high dock score and number of interactions. Conclusion: These compounds can further be isolated and worked upon for future research. � 2022 Bentham Science Publishers.
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    Natural Compounds as Potential Anti-COVID Agents
    (Bentham Science Publishers, 2022-04-05T00:00:00) Rani, Nidhi; Singh, Randhir; Kumar, Praveen; Sharma, Prerna; Sharma, Vikas
    Background: Since December 2019, COVID-19 has become a new health crisis in the world and has been declared a public health emergency of international concern by WHO. In search of anti-COVID treatment regimen, we applied molecular docking approach in order to identify the natural compounds that may have potential for anti-COVID treatment with specific target and selective inhibitory mechanism. Our goal is to identify the potential anti-COVID compounds based on virtual screening of the protein of spike glycoprotein as virtual inhibition target. Methods: Molecular docking was carried out by using Molergo Virtual Docker. 35 compounds from different plant sources were selected and docked in the enzyme pocket. Results: The docking result revealed that some of the compounds exhibited good potency against the virus and can be used further for developing new drug regimen. Conclusion: The compounds of natural origin could be a good target and can be used as lead compounds for the treatment of this dreadful disease. � 2023 Bentham Science Publishers.
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    Chemical Constituents Based Approach for the Management of Diabetes
    (Bentham Science Publishers, 2022-03-23T00:00:00) Sharma, Prerna; Rani, Nidhi; Gangwar, Aishwarya; Dahiya, Randhir Singh; Verma, Nitin
    Background: A number of complexities in compliance with long-term diabetes have been elicited. It has become a global concern without any convincing medicinal, therapeutical methodology. Both hyperglycaemia and oxidative pressure are major notable parts that play a significant role in the initialization of diabetic inconvenience. Natural medications have gained a lot of attention in recent years as expected restorative specialists in the prevention and treatment of diabetic complications due to their many objectives and less poisonous outcomes. This survey means to evaluate the accessible information on therapeutic spices for constriction and the executives of diabetic complications. Materials and Methods: Bibliographic investigation was accomplished by checking old-style course books and papers, directing overall bases of logical information (SCOPUS, PUBMED, SCIELO, Google Scholar, NISCAIR,) to recapture accessible distributed writing. For the assessment of plants with the potential in calming diabetic complications, several inclusion models rely on the numerous medicinal spices as well as their crucial mixes. Furthermore, several models, including plants, have been considered, each of which has a suitable impact on increasing oxidative pressure in diabetes. Results: Different therapeutic plants/plant withdrawals containing alkaloids, terpenoids, phenolic compounds, flavonoids, saponins, and phytosterol-type synthetic constituents were uncovered that are profitable in the administration of diabetic complexities. Results may be attributed to the improvement of oxidative pressure, constant hyperglycemia, and twitch of different metabolic pathways related to the pathogenesis of diabetic confusions. Conclusion: An optimistic approach for new medication terminology to treat diabetic confusion is screening compound competitors from homegrown medication. Investigation of the activity of different plant extracts as well as their potency profile and to determine their job in the treatment of diabetic inconveniences must be there. In addition, an ideal rat model which imitates human diabetic complications ought to be created. � 2023 Bentham Science Publishers.