Pharmaceutical Sciences and Natural Products - Research Publications

Permanent URI for this collectionhttps://kr.cup.edu.in/handle/32116/56

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Author: search.filters.author.Gupta, Vinay Kumar

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    Impact of ABC transporters, glutathione conjugates in MDR and their modulation by flavonoids: An overview
    (2014) Gupta, Vinay Kumar; Bhalla, Yashika; Jaitak, Vikas
    Overexpression of ATP-binding cassette (ABC) transporter and glutathione conjugates results in efflux of cytotoxic agent from tumor cells leading to multidrug resistance (MDR). Many MDR inhibitors have been identified but none of them have been proven clinically valuable without side effects. Efforts are continue to develop an ideal MDR inhibitor. Recently, herbal modulation of ABC transporter and glutathione conjugates by flavonoids is emerging as popular therapy in MDR. In this review, we have covered structure, function of different ABC transporters and glutathione-mediated MRP overexpression. This review also focuses on the problems with existing MDR inhibitors, modulation of ABC transporter and glutathione-S-transferase by flavonoids. ? 2013 Springer Science+Business Media New York.
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    Anticancer activity of essential oils: A review
    (2013) Bhalla, Yashika; Gupta, Vinay Kumar; Jaitak, Vikas
    Natural essential oil constituents play an important role in cancer prevention and treatment. Essential oil constituents from aromatic herbs and dietary plants include monoterpenes, sesquiterpenes, oxygenated monoterpenes, oxygenated sesquiterpenes and phenolics among others. Various mechanisms such antioxidant, antimutagenic and antiproliferative, enhancement of immune function and surveillance, enzyme induction and enhancing detoxification, modulation of multidrug resistance and synergistic mechanism of volatile constituents are responsible for their chemopreventive properties. This review covers the most recent literature to summarize structural categories and molecular anticancer mechanisms of constituents from aromatic herbs and dietary plants. ? 2013 Society of Chemical Industry.