Pharmaceutical Sciences and Natural Products - Research Publications

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    Chemical composition and biological activity of essential oils of dracocephalum heterophyllum benth And Hyssopus officinalis L Collected wild from Western Himalay
    (Sage, 2015) Stappena, Iris; Wannerb Jürgen; Tabanca, Nurhayat; Wedge, David E.; Ali, Abbas; Kaul, Vijay K.; Lal, Brij; Jaitak, Vikas; Gochev, Velizar K.; Schmidt, Erich; Jirovetz, Leopold
    The essential oils of two representatives of the Lamiaceae, Dracocephalum heterophyllum Benth. and Hyssopus officinalis L., are described for their antifungal, antibacterial, larvicidal and inect biting deterrent activities. Additionally, the chemical compositions of the essential oils, analyzed by simultaneous GC-MS and GC-FID, and odor descriptions are given. The main components of H. officinalis oil were pinocarvone, cis-pinocamphone, and ?-pinene. Citronellol was found as the main compound of D. heterophyllum essential oil. Antibacterial testing by agar dilution assay revealed greater activity of D. heterophyllum against Staphylococcus aureus compared with H. officinalis. D. heterophyllum essential oil also showed promising antifungal activity against Colletotrichum species and was more toxic to Aedes aegypti larvae in a larvicial bioassay. Both essential oils showed high activity in the biting deterrent bioassay.
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    Essential Oils: An Impending Substitute of Synthetic Antimicrobial Agents to Overcome Antimicrobial Resistance
    (Bentham Science, 2019) Pal, Rajinder; Rana, Abhilash; Jaitak, Vikas
    ntimicrobial resistance (AMR) is an emerging problem in the world that has a significant impact on our society. AMR made conventional drugs futile against microorganisms and diseases untreatable. Plant-derived medicines are considered safe alternatives to synthetic drugs. The active ingredients and the mixtures of these natural medicines have been used for centuries, due to their easy availability, low cost, and negligible side effects. Essential oils (EOs) are the secondary metabolites that are produced by aromatic plants to protect them from microorganisms. However, these EOs and their constituents have shown good fighting potential against drug-resistant pathogens. These oils have been proved extremely effective antimicrobial agents in comparison to antibiotics. Also, the combination of synthetic drugs with EOs or their components improves their efficacy. So, EOs can be established as an alternative to synthetic antimicrobial agents to eradicate tough form of infectious microorganisms. Due to a number of constituents, it can interact with multiple target sites, like the destruction of cytoplasm membrane or inhibition of protein synthesis and efflux pump. The purpose of this review is to provide information about the antimicrobial activity of EOs attained from different plants, their combination with synthetic antimicrobials. In addition, mechanism of antimicrobial activity of several EOs and their constituents was reported.
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    Chemical composition and biological activity of essential oils of dracocephalum heterophyllum and hyssopus officinalis from western himalaya
    (Natural Product Incorporation, 2015) Stappen I.; Wanner J.; Tabanca N.; Wedge D.E.; Ali A.; Kaul V.K.; Lal B.; Jaitak V.; Gochev V.K.; Schmidt E.; Jirovetz L.
    The essential oils of two representatives of the Lamiaceae, Dracocephalum heterophyllum Benth. And Hyssopus officinalis L., are described for their antifungal, antibacterial, larvicidal and inect biting deterrent activities. Additionally, the chemical compositions of the essential oils, analyzed by simultaneous GC-MS and GC-FID, and odor descriptions are given. The main components of H. officinalis oil were pinocarvone, cis-pinocamphone, and-pinene. Citronellol was found as the main compound of D. heterophyllum essential oil. Antibacterial testing by agar dilution assay revealed greater activity of D. heterophyllum against Staphylococcus aureus compared with H. officinalis. D. heterophyllum essential oil also showed promising antifungal activity against Colletotrichum species and was more toxic to Aedes aegypti larvae in a larvicial bioassay. Both essential oils showed high activity in the biting deterrent bioassay.