Pharmaceutical Sciences and Natural Products - Research Publications

Permanent URI for this collectionhttps://kr.cup.edu.in/handle/32116/56

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Subject: search.filters.subject.Carbazole

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    Naturally available nitrogen-containing fused heterocyclics as prospective lead molecules in medicinal chemistry
    (Bentham Science Publishers, 2020-02-17T00:00:00) Bhardwaj, Nivedita; Pathania, Akashdeep; Kumar, Pradeep
    Heterocyclic compounds constitute one of the largest and most versatile families of organic compounds. There are many heterocyclic compounds that are being isolated from natural sources and day by day the number is increasing rapidly due to their enormous utili-ty. Nitrogen containing heterocyclic compounds have a prominent role in medicinal chemis-try, biochemistry and other streams of science. In this review, we have covered most of the biologically active nitrogen containing heterocyclic compounds obtained from the natural sources including indole, carbazole, quinoline, isoquinoline and benzothiazole ring system. These isolated nitrogen containing heterocyclic compounds render wide spectrum of biological activities including antifungal, anti-inflammatory, antibacterial, antioxidants, anticonvul-sant, anti-allergic, herbicidal and anticancer activities. � 2021 Bentham Science Publishers.
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    C-N and N-N bond formation via reductive cyclization: Progress in cadogan/cadogan-sundberg reaction
    (Wiley-Blackwell, 2018) Kaur, M.; Kumar, Raj
    Cadogan/Cadogan-Sundberg cyclization reaction has been reported as one of the most efficient routes for the synthesis of a wide variety of N-heterocycles from the easily accessible starting materials such as o-nitrobiaryls or o-nitroarenes, onitrostyrenes by treating with tetravalent phosphorus compounds (trialkyl or triaryl phosphines or trialkyl phosphites). The reaction has been successfully employed in Carbon-Carbon as well as Carbon-Nitrogen bond formation for the scaffolds like carbazole, indoles, coumarins, and indazoles. To the best of authors'knowledge, the present review is the first compilation of the literature from almost two decades (2000 to present) on Cadogan/Cadogan-Sundberg cyclization reaction, its scope, mechanistic aspects, and limitations.