Pharmaceutical Sciences and Natural Products - Research Publications

Permanent URI for this collectionhttps://kr.cup.edu.in/handle/32116/56

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Subject: search.filters.subject.Essential oils

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    Polymeric Encapsulates of Essential Oils and Their Constituents: A Review of Preparation Techniques, Characterization, and Sustainable Release Mechanisms
    (Taylor and Francis Inc., 2016) Vishwakarma, G.S.; Gautam, N.; Babu, J.N.; Mittal, S.; Jaitak, Vikas
    Natural polymer based encapsulation of essential oil (EO) is one of the emerging and challenging area of research in perfumery, cosmetics, flavoring agents, preservatives, therapeutics, etc. The knowledge of formulation techniques and physico-chemical properties of the polymers are the basic requirements for the successful encapsulations of essential oils (EOs). This current review article is focused on a comparative account of various formulation techniques based on their applicability. For the first time, it also reviews various physico-chemical techniques used in the analysis of EO encapsulates to determine their stability, structure, surface morphology, and encapsulation efficiency. Further, the mechanisms involved in the release of EOs from encapsulates, along with various factors affecting their release, have also been discussed. ? 2016 Taylor & Francis Group, LLC.
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    An in-silico approach on essential oil molecules as apoptosis inducer in cancer chemotherapy
    (Innovations in Pharmaceuticals and Pharmacotherapy, 2017) Bhalla, Yashika; Singla, Ramit; Jaitak, Vikas; Sapra, Sameer
    Essential oils (EOs) are very engrossing natural plant products and apart from this they possess various biological properties. It has been reported that these essential oil molecules are able to inhibit tumor cell proliferation and induce tumor cell death by inhibiting multiple cancer-specific targets including the suppression of anti-apoptotic pathways i.e., BCL-2, BCL-XL, MCL-1, and NFκb. This study was conducted with the objective of exploring the anticancer activity of herbs and spices, with special reference to its potential to inhibit anti-apoptotic pathways by studying their interaction pattern with the selective inhibitors of the particular receptors. Hence a comparative in-silico study was done in which the essential oil molecules were docked with specific anti-apoptotic receptors with respect to the particular known inhibitor of that receptor therefore the binding affinity of the essential oil molecule with that of the receptor site was analyzed. It has been observed that the phytochemicals like capsaicin have an impressive binding affinity for NFκb receptor, BCL-2 as compared to its standard inhibitors, which shows that the phytochemical has stronger binding affinity for receptor. These docking results hereby apparently tells us that the binding affinity of the essential oil molecules are either comparable or more than that of the specific inhibitors of the receptors hence in future drug molecules can be synthesized keeping in view the strong binding affinity of these molecules with the receptors.