Human Genetics And Molecular Medicine - Research Publications

Permanent URI for this collectionhttps://kr.cup.edu.in/handle/32116/107

Browse

Author: search.filters.author.Chander, H.

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Complex roles of discoidin domain receptor tyrosine kinases in cancer
    (Springer Science and Business Media Deutschland GmbH, 2021-02-25T00:00:00) Mehta, V.; Chander, H.; Munshi, A.
    Discoidin domain receptors, DDR1 and DDR2 are members of the receptor tyrosine kinase (RTK) family that serves as a non-integrin collagen receptor and were initially identified as critical regulators of embryonic development and cellular homeostasis. In recent years, numerous studies have focused on the role of these receptors in disease development, in particular, cancer where they have been reported to augment ECM remodeling, invasion, drug resistance to facilitate tumor progression and metastasis. Interestingly, accumulating evidence also suggests that DDRs promote apoptosis and suppress tumor progression in various human cancers due to which their functions in cancer remain ill-defined and presents a case of an interesting therapeutic target. The present review has discussed the role of DDRs in tumorigenesis and the metastasis. � 2021, Federaci�n de Sociedades Espa�olas de Oncolog�a (FESEO).
  • Thumbnail Image
    Item
    High expression of FBP17 in invasive breast cancer cells promotes invadopodia formation
    (Humana Press Inc., 2018) Suman, Prabhat; Mishra, Sarthak; Chander, Harish; Suman, P.; Mishra, S.; Chander, H.
    Metastatic spread of the cancer is usually the consequence of the activation of signaling pathways that generate cell motility and tissue invasion. Metastasis involves the reorganization of cytoskeleton and cell shape for the swift movement of the cells through extracellular matrix. Previously, we have described the invasive and metastatic role played by one of the members (Toca-1) of CIP4 subfamily of F-BAR proteins. In the present study, we address the role of another member (FBP17) of same family in the invasion breast cancer cells. Here, we report that the formin-binding protein 17 (FBP17) is highly expressed at both mRNA and protein levels in breast cancer cells. The study showed the association of FBP17 with cytoskeletal actin regulatory proteins like dynamin and cortactin. To determine its role in extracellular matrix (ECM) degradation, we achieved stable knockdown of FBP17 in MDA-MB-231 cells. FBP17 knockdown cells showed a defect and were found to be compromised in the degradation of ECM indicating the role of FBP17 in the invasion of breast cancer cells. Our results suggest that FBP17 is highly expressed in breast cancer cells and facilitates the invasion of breast cancer cells. ? 2018, Springer Science+Business Media, LLC, part of Springer Nature.