Human Genetics And Molecular Medicine - Research Publications

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Author: search.filters.author.Senapati, SabyasachiSubject: search.filters.subject.Systematic review

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    Celiac disease poses significant risk in developing depression, anxiety, headache, epilepsy, panic disorder, dysthymia: A�meta-analysis
    (Springer, 2021-11-28T00:00:00) Sharma, Nidhi; Singh, Kavita; Senapati, Sabyasachi
    Celiac disease (CD) primarily affects the small intestine. Previous studies have identified higher incidences of neuropsychiatric diseases among CD patients compared to non-CD controls. Genome-wide association studies have identified >60 non-human leukocyte antigen (HLA) genes associated with CD, where estimated 15% genes have role in neurological health. We carried out a systematic review and meta-analysis to estimate the potential risk conferred by CD in developing neuropsychiatric diseases. Literature search was performed till June 2019. Incidences of neuropsychiatric diseases were compared among CD and non-CD controls. Funnel plots and Egger�s tests were used to evaluate publication bias and estimate study effects. Qualities of the included studies were estimated using Newcastle-Ottawa Scale. Quality of evidence was graded using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Odds of developing neuropsychiatric diseases among CD were evaluated by computing meta-odds ratio (Manten-Haenszel method) and Z test p-value using random and fixed effect�models based on the degree of study heterogeneity. Thirteen non-randomized case-control studies were found eligible. Subjects suffering from CD were found to have significantly more risk to develop depression (p<1.00E-05; OR=1.60 [1.37�1.86]), anxiety (p=0.05; OR=1.41 [1.00�1.97]), headache (p<0.1.00E-05; OR=3.27 [2.46�4.34]), epilepsy (p<1.00E-04; OR=11.90 [3.78�37.43]), panic disorder (p<1.00E-04; OR=4.64 [2.22�9.70]), and dysthymia (p=2.00E-03; OR=5.27 [1.83�15.22]). CD is a major predisposing factor in developing array of common neuropsychiatric diseases. Shared biological processes and molecular networks could play a crucial role in disease co-occurrence. Detailed molecular evidences are needed to establish the cause-effect relationship between these diseases. � 2021, Indian Society of Gastroenterology.
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    Serum homocysteine could be used as a predictive marker for chronic obstructive pulmonary disease: A meta-analysis
    (Frontiers Media S.A., 2019) Chaudhary, D; Sharma, N; Senapati, Sabyasachi
    Background: Serum homocysteine (Hcy) level is inversely related with concentration of folic acid, which is an essential micronutrient for metabolism and energy homeostasis. Serum concentrations of Hcy have been reported to have strong correlation with smoking, which is a major risk factor for pathogenesis of chronic obstructive pulmonary disease (COPD) irrespective of ethnicity and gender. Therefore, we performed a systematic review based meta-analysis to evaluate the overall contribution of Hcy in COPD. Method: Published literature on association of serum Hcy with COPD were obtained through conventional web search and eligible literature were selected based on stringent inclusion/exclusion criteria. Continuous variable data was presented as mean and standard deviation. The variable data was analyzed using RevMan 5 statistical tool to meta-analyze mean differences (MD) with 95 % CI for case-control studies. Result: Four case-control studies met the inclusion criteria for this study. A total of 145 COPD subjects and 107 healthy controls were analyzed. Elevated serum homocysteine concentration was found to induce risk for COPD (MD = 3.05). Conclusion: Molecular role of Hcy in COPD pathogenesis or prognosis is not clear but existing literature suggests that smoking disturbs folic acid metabolism and promotes Hcy accumulation. This study suggested the contribution of Hcy in COPD pathogenesis. However, large scale prospective cohort study and replication studies with more power are warranted to confirm the results. © 2019 Chaudhary, Sharma and Senapati.