Pharmaceutical Sciences and Natural Products - Master Dissertation
Permanent URI for this collectionhttps://kr.cup.edu.in/handle/32116/53
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Item Synthesis And Antiproliferative Activity Of Pyrazole-Based Heterocycles(Central University of Punjab, 2018) Pandey, Vishakha; Kumar, RajAmong the various heterocyclic compounds pyrazole and its derivatives have occupied wide range of biological and pharmacological activities. These were observed for their modes of function in the inhibition of topoisomerase and DNA repair. DNA topoisomerases usually modify DNA topology by their ability to break and reseals both its strands. Which were leads to DNA replication, transcription processes. It helps as a vital targets for numerous chemotherapeutic agents. The potency of topoisomerase inhibitors looks to be diminishing due to drug resistance and lack of efficacy. Thus, after long glimpsing the current scenario was made in order to develop topoisomerase inhibitors with completely new scaffold or alteration or modification in the existing scaffold. We herein report design and synthesis of pyrazole based compounds as topoisomerase inhibitors. The synthetics were evaluated for their in vitro anticancer activity against MDAMB 231 breast cancer cell line.Item Synthesis, Characterization and Biological Evaluation of 5-(2- Nitrophenyl)-1H-Pyrazole Derivatives as Putative Antiproliferative Agents(Central University of Punjab, 2018) Saini, Geetika; Kumar, RajPyrazoles are known to exhibit various biological activities like antibacterial, antiprotozoal, anticonvulsant, analgesic, anti-inflammatory, antiviral and antiproliferative. An attempt has been made to synthesize substituted pyrazoles. Their antiproliferative activity was determined by performing MTT assay on MDA-MB 231 cell line (breast cancer). The compounds were further docked into topoisomerase 1 and 2Item Synethesis and biochemical screening of novel non-purine based xanthine oxidase inhibitors(Central University of Punjab, 2013) Kumar, Deependra; Kumar, RajXanthine oxidase (XO), or xanthine oxidoreductase (XOR), is a complex molybdoflavoenzyme which, in humans, is recognized as the terminal enzyme of purine catabolism, catalysing the hydroxylation of purines to uric acid, overproduction of which usually leads to a pathological condition called hyperuricemia and gout. XO inhibitors (XOI) are proved to be promising urate lowering agents. Purine based XOI (allopurinol) however, are associated with various lethal side effects like hypersensitivity syndrome (Stevens Johnson syndrome and Tissue Epidermal Necrolysis), bone marrow depression, rash etc. On the other hand non-purine based XOI (febuxostat) are found to be safer and effective antihyperuricemic and antigout agents. Present investigation describes synthesis, characterization of some non-purine based compounds and their evaluation for xanthine oxidase inhibitory activity