Department Of Pharmacology

Permanent URI for this communityhttps://kr.cup.edu.in/handle/32116/108

Browse

Author: search.filters.author.Goyal, Ahsas

Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Daidzein Attenuates Ovariectomy-Induced Cognitive Deficits by Improving Cortical Endothelial Function in Rats
    (Springer Science and Business Media Deutschland GmbH, 2023-07-17T00:00:00) Jaiswal, Salok; Goyal, Ahsas; Garabadu, Debapriya
    There have been reports of decreased vascular activity in memory-sensitive brain areas, which is thought to be a different approach to managing cognitive deficiencies in females with estrogen insufficiency. Daidzein, a plant-derived phytoestrogen, facilitates cerebral blood flow in normal animals and also improves vascular activity in the peripheral tissues of the ovariectomized animal. However, its neuroprotective activity in vascular function has not yet been established in ovariectomized animals. Hence, the present study explored the caveolin-1/eNOS/VEGF-mediated signaling in the anti-amnesic ability of daidzein in ovariectomized rats. On day 5 of the Morris water maze experiment, female rats with bilateral ovariectomy displayed amnesia as measured by an increase in both escape latency and time spent in the targeted quadrant. Further, ovariectomy reduced blood flow and the level of expression of vascular endothelial growth factor in rat cortical tissues. In addition, ovariectomy diminished the acetylcholine level, increased the acetylcholinesterase activity, and increased oxidative stress in rat cortical tissues. Daidzein attenuated ovariectomy-induced alterations in behavioral, vascular, cholinergic, and oxidative stress in the animals. These beneficial effects of daidzein were abolished with N-nitro-l-arginine methylester (L-NAME), which inhibits endothelial nitric oxide synthase, in the ovariectomized rat model. These observations emphasize the fact that daidzein potentially exerts anti-amnesic activity perhaps through the caveolin-1/eNOS/VEGF-mediated signaling pathway in ovariectomy-induced cognitive-deficit rats. Therefore, daidzein holds the potential as a therapeutic option for the treatment of cognitive deficits in postmenopausal women. Graphical Abstract: [Figure not available: see fulltext.]. � 2023, The Author(s) under exclusive licence to Sociedade Brasileira de Farmacognosia.
  • No Thumbnail Available
    Item
    Role of caveolin-eNOS platform and mitochondrial ATP-sensitive potassium channel in abrogated cardioprotective effect of ischemic preconditioning in postmenopausal women
    (Faculdade de Ciencias Farmaceuticas (Biblioteca), 2022-12-16T00:00:00) Goyal, Ahsas; Agrawal, Neetu; Jain, Ankit; Gupta, Jeetendra Kumar; Garabadu, Debapriya
    Caveolin, the protein of the caveolar membrane, interacts and binds with endothelial nitric oxide synthase (eNOS), forming a caveolin-eNOS complex leading to suppression of the eNOS activity. Caveolin, therefore, maintains eNOS in the inactivated state leading to reduced nitric oxide (NO) production. Ischemic preconditioning disrupts the caveolin-eNOS complex leading to activation of the eNOS and thus results in cardioprotection. During ischemic preconditioning, NO produces cardioprotection by the opening of the KATP channel, and the caveolin forms a suitable signalling platform facilitating the interaction of NO with the KATP channel. Estrogen deficiency has been reported to upregulate caveolin-1 expression. The article aims to review the various mechanisms that placed the women at the risk of coronary artery diseases after postmenopausal estrogen deficiency and their role in the cardioprotective effect of ischemic preconditioning. � 2022, Faculdade de Ciencias Farmaceuticas (Biblioteca). All rights reserved.
  • No Thumbnail Available
    Item
    A Comprehensive Review on Preclinical Evidence-based Neuroprotective Potential of Bacopa monnieri against Parkinson's Disease
    (Bentham Science Publishers, 2022-03-17T00:00:00) Goyal, Ahsas; Gopika, Sainu; Kumar, Abhishek; Garabadu, Debapriya
    Parkinson's disease is a chronic and gradually progressive neurodegenerative disorder trig-gered due to the loss of dopamine-releasing neurons in the region of substantia nigra pars compacta characterized by the motor symptoms, such as tremor, bradykinesia, akinesia, and postural instability. Proteinopathies, mitochondrial dysfunction induced dopaminergic neuronal deterioration, and gene mutations are the hallmarks of Parkinson's disease. The bioactive components of Brahmi, such as Bacoside A, Bacoside B, and Bacosaponins, belong to various chemical families. Brahmi's neuropro-tective role includes reducing neuronal oxidative stress, dopaminergic neuronal degeneration, mito-chondrial dysfunction, inflammation, inhibition of ?-synuclein aggregation, and improvement of cognitive and learning behaviour. Researchers found that Bacopa monnieri significantly increased brain levels of glutathione, vitamin C, vitamin E, and vitamin A in rats exposed to cigarette smoke. Brahmi has a potent antioxidant property and neuroprotective effects against PD that help reduce oxidative stress and neuroinflammation and enhance dopamine levels. The review collates all the preclinical studies that prove the beneficial neuroprotective effect of Brahmi for treating PD. � 2022 Bentham Science Publishers.