Department Of Pharmacology

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Author: search.filters.author.Kumar, PuneetSubject: search.filters.subject.Flavonoids

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    Treatment of diabetic complications: do flavonoids holds the keys?
    (Taylor and Francis Ltd., 2023-07-12T00:00:00) Chalotra, Rishabh; Gupta, Tanya; Chib, Shivani; Amanat, Muhammed; Kumar, Puneet; Singh, Randhir
    Diabetes mellitus (DM) is an endocrinological disorder in which blood sugar levels get elevated and if unmanaged, it leads to several critical complications. Existing therapies or drugs are not able to attain absolute control of DM. Moreover, associated side/adverse effects associated with pharmacotherapy further worsen the Quality of life of patients. Present review is focused on therapeutical potential of flavonoids in management of diabetes and diabetic complications. Plenteous literature has established significant potential of flavonoids in the treatment of diabetes and diabetic complications. A number of flavonoids are found to be effective in treatment of not only diabetes but progression of diabetic complication was also found to be attenuated with the use of flavonoids. Moreover, SAR studies of some flavonoids also indicated the that efficacy of flavonoids is increased with a change in functional group of flavonoids in the treatment of diabetes and diabetic complications. A number of clinical trials are into action to investigate the therapeutic potential of flavonoids as first-line drugs or as adjuvants for treatment of diabetes and diabetic complications. Owing to their diverse mechanism of action, efficacy and safety, flavonoids may be conscripted as potential candidate for treatment of diabetic complications. � 2023 Taylor & Francis Group, LLC.
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    Natural Products as an Alternative Therapy for Brain Tumors: From Bench To Bedside
    (Springer Singapore, 2022-09-28T00:00:00) Kumar, Sachin; Kumar, Mandeep; Bijalwan, Anjali; Sharma, Shubham; Kumar, Puneet
    Incremental elevation in the trends of a brain tumor in recent years accounts for 5% adult population, whereas the number exceeds 70% in the case of children. Evidence reveals an eventual metastasize of 20%-30% of malignant tumors to the brain�s different regions. Compression in the brain tissue and elevated intracranial pressure mediated by benign and malignant tumors contributed to severe consequences like the central nervous system (CNS) damage or even imperil the patient�s life. Despite multiple therapeutic strategies in the market, none of the drugs are fully effective and safe. Strategic advancement indicates chemotherapy as a treatment of choice for critical conditions like brain tumors, but the chemotherapy drugs toxicity is still a major therapeutic hurdle. Plants and their derived natural products are one of the most emerging targets to strike against brain tumors. Analogs of several natural products are already demonstrated as antitumor in nature, and day by day, advancements unfold various other plant and plant derivatives having such antitumor activity. This chapter aims to underline and emphasize the antitumor agents, which can target brain tumors procured from the natural origin such as natural products and their analogs. The available data on different plants and isolated compounds of natural origin used to reduce and arrest brain tumors is also discussed here. � Springer Nature Singapore Pte Ltd. 2022.