Department Of Chemistry

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    Cu(II)-Catalysed Azide-Alkyne Cycloaddition Reaction towards Synthesis of ?-Carboline C1-Tethered 1,2,3-Triazole Derivatives
    (John Wiley and Sons Inc, 2021-04-27T00:00:00) Kumar, Sunit; Malakar, Chandi C.; Singh, Virender
    Indole and ?-carboline alkaloids exhibit diverse range of significant pharmacological properties as reflected by their contribution in drug-discovery. We have described the synthesis of hybrid molecules containing ?-carboline C1-linked 1,2,3-triazoles in moderate to good yields. The developed transformation was realized by using Cu(II)-catalysed click-reaction of diverse alkynes with in-situ derived rarely explored ?-carboline tethered aliphatic azides. These molecular hybrids also exhibited excellent fluorescence properties. � 2021 Wiley-VCH GmbH