Department Of Chemistry

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Author: search.filters.author.Jamra, RahulSubject: search.filters.subject.Kumujian C

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    Iodine-Catalysed Synthesis of ?-Carboline Tethered ?-Amino Amidines Through Ugi-Type Multicomponent Reaction
    (John Wiley and Sons Inc, 2022-09-15T00:00:00) Singh, Manpreet; Vaishali; Jamra, Rahul; Deepika; Kumar, Sunit; Singh, Virender
    A simple and efficient iodine catalysed protocol has been unfolded for the synthesis of novel ?-carboline C1-linked ?-amino amidines via one-pot assembly of 1-formyl ?-carbolines (Kumujian C analogues), anilines and isocyanides. This domino strategy proceeds through the formation of three C?N bonds in a single operation. The advantageous features of the developed methodology include one-pot synthesis, operational simplicity, high atom economy, broad substrate scope, multicomponent character, easy purification procedure (no column chromatography) and applicability towards gram scale synthesis. The scope of strategy has been demonstrated with the construction of a library of 32 novel ?-carboline tethered ?-amino amidines having three points of diversity. � 2022 Wiley-VCH GmbH.
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    Potassium Tert-Butoxide-Promoted Synthesis of Fluorescent ?-Carboline Tethered 1,3,5-Triazines and Assessment of Their Luminescent Properties
    (John Wiley and Sons Inc, 2021-07-05T00:00:00) Singh, Manpreet; Jamra, Rahul; Mehra, Saloni; Rattan, Sunita; Singh, Virender
    A transition metal-free, base-mediated efficient synthesis of novel ?-carboline C1(3) tethered triazines has been accomplished by using ?-carboline alkaloid; Kumujian C as a template for reaction with readily available amidines. The strategy has been found compatible with diverse 1(3)-formyl ?-carbolines and amidines, providing access to wide variety of novel ?-carboline linked 1,3,5-triazines in good to excellent yields. The methodology is also amenable to gram scale synthesis of triazines. The presented methodology features sustainable reaction conditions, clean and simple methodology, low environmental impact, wide substrate scope and high atom economy with good to excellent yields. Moreover, the light emitting properties of these fluorescent ?-carboline linked triazine derivatives were investigated for the first time where quantum yield (?F) up to 60% was obtained. � 2021 Wiley-VCH GmbH