Department Of Chemistry

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Author: search.filters.author.Kumar, SunitSubject: search.filters.subject.Kumujian C

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    Iodine-Catalysed Synthesis of ?-Carboline Tethered ?-Amino Amidines Through Ugi-Type Multicomponent Reaction
    (John Wiley and Sons Inc, 2022-09-15T00:00:00) Singh, Manpreet; Vaishali; Jamra, Rahul; Deepika; Kumar, Sunit; Singh, Virender
    A simple and efficient iodine catalysed protocol has been unfolded for the synthesis of novel ?-carboline C1-linked ?-amino amidines via one-pot assembly of 1-formyl ?-carbolines (Kumujian C analogues), anilines and isocyanides. This domino strategy proceeds through the formation of three C?N bonds in a single operation. The advantageous features of the developed methodology include one-pot synthesis, operational simplicity, high atom economy, broad substrate scope, multicomponent character, easy purification procedure (no column chromatography) and applicability towards gram scale synthesis. The scope of strategy has been demonstrated with the construction of a library of 32 novel ?-carboline tethered ?-amino amidines having three points of diversity. � 2022 Wiley-VCH GmbH.
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    Cu(II)-Catalysed Azide-Alkyne Cycloaddition Reaction towards Synthesis of ?-Carboline C1-Tethered 1,2,3-Triazole Derivatives
    (John Wiley and Sons Inc, 2021-04-27T00:00:00) Kumar, Sunit; Malakar, Chandi C.; Singh, Virender
    Indole and ?-carboline alkaloids exhibit diverse range of significant pharmacological properties as reflected by their contribution in drug-discovery. We have described the synthesis of hybrid molecules containing ?-carboline C1-linked 1,2,3-triazoles in moderate to good yields. The developed transformation was realized by using Cu(II)-catalysed click-reaction of diverse alkynes with in-situ derived rarely explored ?-carboline tethered aliphatic azides. These molecular hybrids also exhibited excellent fluorescence properties. � 2021 Wiley-VCH GmbH