Department Of Chemistry

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Subject: search.filters.subject.Amides

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    Synthesis and Characterization of Novel Pd@rGO?CuFe2O4 Magnetic Nanoparticles: A Recyclable Catalyst for C?C Coupling Reaction in Biomass-Derived Organic Solvent
    (John Wiley and Sons Inc, 2023-10-06T00:00:00) Teli, Yaqoob A.; Reetu, Reetu; Singh, Priyanka Gurdev; Patel, Mayur Jagdishbhai; Dash, Sonali; Paine, Snehangshu; Prabhakar, Poornachandra Shamanna; Singh, Virender; Keremane, Kavya S.; Al-Zaqri, Nabil; Mukherjee, Kalisadhan; Dutta, Saikat; Malakar, Chandi C.
    Development of new, cost effective, stable heterogeneous catalyst for the organic transformations is an important thematic area of research. Present work describes the development of new Pd@rGO?CuFe2O4 catalyst and demonstrates its effectiveness for Suzuki-Miyaura type coupling reactions. The additional advantage of this reaction is its feasibility using biomass-derived solvent like ?-Valerolactone (GVL) in aqueous media. The catalyst is prepared hydrothermally and characterized using XRD, FESEM, EDX, and XPS analysis. The catalyst exhibits excellent activity and recyclability (up to six times) in the C?C coupling reaction to deliver the corresponding biaryl molecules in yields up to 90 %. High efficiency for the conversion of nitriles to amides is also revealed by the prepared catalyst. � 2023 Wiley-VCH GmbH.
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    Metal-Free Direct Access to N-Sulfonyl Amidines from Sulfonamides and Secondary Amines Involving Tandem C-N Bond Formations
    (American Chemical Society, 2022-08-17T00:00:00) Nishad, Chandra Shekhar; Haldar, Krishna Kanta; Banerjee, Biplab
    We report a mild and efficient metal-free one-pot procedure for the synthesis of N-sulfonyl amidines via the direct reaction of sulfonamides with secondary amines without using any additives. A wide range of substrates with variety of functional groups is well tolerated under the reaction conditions. Preliminary mechanistic studies indicate that the secondary amine plays a dual role as a C1 source of the amidine group and an aminating agent. Synthetic utility of this method is shown in the late-stage functionalization of drug molecules on the gram scale. � 2022 American Chemical Society.
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    A dual stimuli responsive natural polymer based superabsorbent hydrogel engineered through a novel cross-linker
    (Royal Society of Chemistry, 2021-03-23T00:00:00) Mehra, Saloni; Nisar, Safiya; Chauhan, Sonal; Singh, Gurmeet; Singh, Virender; Rattan, Sunita
    Natural protein-based polymers may serve as a potential source for developing advanced porous organic macromolecules, possessing exquisite control over the pores, which impart exceptional properties to these materials. Here, we describe a strategy to design, synthesize and develop an intelligent, dual stimuli responsive highly porous grafted polymer with exquisite control over the functionality of pores. The monomer 2-(4-((acrylamido)methyl)-1H-1,2,3-triazol-1-yl)-4-vinylbenzoic acid as a cross-linker, having pH responsive (acidic functional groups) and thermo-responsive (triazole and acrylamide groups) functional groups, was successfully prepared via click chemistry, for grafting onto the backbone of the natural polymer soy protein isolate (SPI) via microwave irradiation. Alkene groups were introduced at both the sides of the monomer, prior to grafting with SPI. Furthermore, to increase the hydrogen bonding network in the polymer, the pH responsive crosslinker 4-(4-hydroxyphenyl)butanoic acid (HPBA) was introduced while grafting. The grafted soy protein isolate polymer, SPI-g-[2-(4-((acrylamido)methyl)-1H-1,2,3-triazol-1-yl)-4-vinylbenzoicacid-co-4-(4-hydroxyphenyl) butanoic acid]-g-SPI, [SPI-g-(ATVBA-co-HPBA)-g-SPI], is characterized by using TGA for thermal stability, SEM and TEM for visual confirmation, NMR, LCMS and FTIR for grafting confirmation, XRD for crystallinity, MTT assay for cytotoxicity, and BET for analyzing the porous network structure. The size and morphological changes of [SPI-g-(ATVBA-co-HPBA)-g-SPI] are studied under different parameters for its potential use as an advanced porous macromolecule based superabsorbent polymer (SAP). � 2021 The Royal Society of Chemistry.