Department Of Chemistry

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Subject: search.filters.subject.Heterogeneous catalyst

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    Synthesis and Characterization of Novel Pd@rGO?CuFe2O4 Magnetic Nanoparticles: A Recyclable Catalyst for C?C Coupling Reaction in Biomass-Derived Organic Solvent
    (John Wiley and Sons Inc, 2023-10-06T00:00:00) Teli, Yaqoob A.; Reetu, Reetu; Singh, Priyanka Gurdev; Patel, Mayur Jagdishbhai; Dash, Sonali; Paine, Snehangshu; Prabhakar, Poornachandra Shamanna; Singh, Virender; Keremane, Kavya S.; Al-Zaqri, Nabil; Mukherjee, Kalisadhan; Dutta, Saikat; Malakar, Chandi C.
    Development of new, cost effective, stable heterogeneous catalyst for the organic transformations is an important thematic area of research. Present work describes the development of new Pd@rGO?CuFe2O4 catalyst and demonstrates its effectiveness for Suzuki-Miyaura type coupling reactions. The additional advantage of this reaction is its feasibility using biomass-derived solvent like ?-Valerolactone (GVL) in aqueous media. The catalyst is prepared hydrothermally and characterized using XRD, FESEM, EDX, and XPS analysis. The catalyst exhibits excellent activity and recyclability (up to six times) in the C?C coupling reaction to deliver the corresponding biaryl molecules in yields up to 90 %. High efficiency for the conversion of nitriles to amides is also revealed by the prepared catalyst. � 2023 Wiley-VCH GmbH.
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    Chitosan-supported FeCl3 catalyzed multicomponent synthesis of tetrahydroisoquinoline-indole hybrids with promising activity against chloroquine resistant Plasmodium falciparum
    (Elsevier B.V., 2022-10-26T00:00:00) Kaur, Pavneet; Sharma, Priyanka; Kumar, Vinod; Sahal, Dinkar; Kumar, Rakesh
    An operationally simple three-component coupling of tetrahydroisoquinoline (THIQ), aldehydes and indoles or indole-3-carboxylic acids has been achieved using chitosan-ionic liquid supported FeCl3 (chit-IL@FeCl3) as a recyclable heterogeneous catalyst. The developed waste-free approach provided rapid access to biologically important THIQ-indole hybrids without the use of any additive or ligand. The synthesized THIQ-indole hybrids were evaluated as antiplasmodial agents against chloroquine-sensitive (Pf3D7) and chloroquine-resistant (PfINDO) strains of Plasmodium falciparum. Compounds 4b (most potent against Pf3D7) and 4g (most potent against PfINDO) showed IC50 values of 1.32 and 0.26 �g/mL respectively. Also, 4g showed strong cytocidal action against both rings and trophozoite stages. Furthermore, cytotoxic study against human liver HUH 7 cells revealed that the most potent compound 4g with an excellent resistance index of 0.07 is also relatively non-toxic. The results of this study suggest that THIQ-indole hybrids hold an enormous potential for developing new antimalarial agents with novel mechanism of action. � 2022 Elsevier B.V.