School Of Health Sciences

Permanent URI for this communityhttps://kr.cup.edu.in/handle/32116/102

Browse

Author: search.filters.author.Chander, HHas files: No

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Mechanisms of Anti-Tumor Activity of Withania somnifera (Ashwagandha)
    (Routledge, 2020) Mehta, V; Chander, H; Munshi, A.
    Increasing herbal formulations have been used to treat several diseases including cancer. W. somnifera (Ashwagandha) is one such plant the extracts of which have been tested against a number of ailments including cancer, which remains as one of the most dreadful diseases on the globe. The ever-increasing number of cancer related mortality demands the development of novel chemopreventive agents with minimum side effects. Different compounds isolated from various parts of the plant like root, stem, and leaves have been reported to display significant anti-cancerous and immunomodulating properties and thus can be used alone or in combination with other chemotherapeutic drugs for cancer treatment. Through this review, we highlight the importance of W. somnifera in countering the potential oncogenic signaling mediators that are modulated by active constituents of W. somnifera in a variety of cancer types. Further, we hope that active constituents of W. somnifera will be tested in clinical trials so that they can be used as an important adjuvant in the near future for the effective treatment of cancer. � 2020, � 2020 Taylor & Francis Group, LLC.
  • No Thumbnail Available
    Item
    Synthesis of gadolinium oxide nanocuboids for in vitro bioimaging applications
    (Institute of Physics Publishing, 2019) Chawda, N; Mishra, S; Basu, M; Chander, H; Podder, R; Mahapatra, S.K; Banerjee, I.
    Undoped and Eu-doped gadolinium oxide (GGNCs and EGNCs) nanocuboids functionalized with D-gluconic acid (GA) were synthesised by a simple yet unique scheme using all the benign solvents and temperature. Samples were characterized and presented with properties like good dispersity, biocompatibility, and stability required for standard contrast agent used in magnetic resonance imaging (MRI) and optical coherence tomography (OCT). Biological assays such as 3-(4, 5-dimethyl-2-yl)-2, 5-diphenyltetrazoliumbromide (MTT) assay, flow cytometry and confocal microscopy were used to determine its biocompatibility, cellular internalization and optical cellular imaging using A549 and H1299 lung cancer cell lines. EGNCs treated with cell lines emitted red fluorescence which was used to track the internalization of EGNCs within the cells. GGNCs sample showed ?20% enhanced MRI relaxivity as compared to EGNCs; whereas EGNCs revealed better contrast in doctor scans of OCT. Samples could be used as promising candidate for other biomedical applications such as drug delivery when equipped with well functionalised drug molecules.