School Of Health Sciences

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    Nutrition and neurological disorders
    (Elsevier, 2023-06-16T00:00:00) Sharma, Prerna; Gangwar, Aishwarya; Rani, Nidhi; Singh, Randhir
    Nutritional intakes, homeostasis of glucose and also of electrolytes, are controlled by the central nervous system which triggers the various sensations. Certain risks are associated with malnutrition that may have severe effects and are a major cause of neurological diseases. About 792 million people from chronic food deficiencies are influenced in the whole world. Acute neurological patients may have a wide range of enhanced metabolism and catabolism seen due to long-term fasting. Acute neurological diseases include spinal cord injuries, traumatic brain injury, cancer, and cerebral vascular accident hemorrhagic or ischemic, whereas chronic neurological diseases include Parkinson's disease, several dementia's and Alzheimer's disease, and amyotrophic lateral sclerosis. Treatment options must include the nutritional evaluation periodically. Also, to rectify the nitrogen balance depletion, intake of nutrition must be enhanced and hyper alimentation must be avoided. � 2023 Elsevier Inc. All rights reserved.
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    Advanced molecular therapies for neurological diseases: focus on stroke, alzheimer's disease, and parkinson's disease
    (Springer-Verlag Italia s.r.l., 2022-09-06T00:00:00) Katta, Madhumitha; Mathew, Blessy Aksa; Chaturvedi, Pragya; Ludhiadch, Abhilash; Munshi, Anjana
    Neurological diseases (NDs) are one of the leading causes of disability and the second leading cause of death globally. Among these stroke, Alzheimer's disease (AD), and Parkinson's disease (PD) are the most common NDs. A rise in the absolute number of individuals affected with these diseases indicates that the current treatment strategies in management and prevention of these debilitating diseases are not effective sufficiently. Therefore, novel treatment strategies are being explored to cure these diseases by addressing the causative mechanisms at the molecular level. Advanced therapies like gene therapy (gene editing and gene silencing) and stem cell therapies aim to cure diseases by gene editing, gene silencing and tissue regeneration, respectively. Gene editing results in the deletion of the aberrant gene or insertion of the corrected gene which can be executed using the CRISPR/Cas gene editing tool a promising treatment strategy being explored for many other prevalent diseases. Gene silencing using siRNA silences the gene by inhibiting protein translation, thereby silencing its expression. Stem cell therapy aims to regenerate damaged cells or tissues because of their ability to divide into any type of cell in the human body. Among these approaches, gene editing and gene silencing have currently been applied in vitro and to animal models, while stem cell therapy has reached the clinical trial stage for the treatment of NDs. The current status of these strategies suggests a promising outcome in their clinical translation. � 2022, Fondazione Societ� Italiana di Neurologia.