Department Of Pharmaceutical Sciences and Natural Products
Permanent URI for this communityhttps://kr.cup.edu.in/handle/32116/52
Browse
2 results
Search Results
Item FDA approved six-membered ring fused pyrimidine-based derivatives(Elsevier, 2022-10-14T00:00:00) Arora, Sahil; Kumar, RajPyrimidine-based derivatives play a vital role in the development of drugs due to their indispensable role in various biological processes. To date, ring fused pyrimidine-based derivatives have been reported to exhibit numerous biological activities including anticancer, antiviral, antianginal, anti-HIV, antifungal, antibacterial, anti-inflammatory, antitubercular and many others. There are numerous synthetic approaches available for the synthesis of fused pyrimidine-based derivatives which provides ample scope in the development of new drugs. Considering these medicinal attributes of fused pyrimidine-based derivatives, we have put forth this book chapter mainly focusing on the FDA approved six-membered ring fused pyrimidine-based derivatives. The present chapter deals with improved synthetic schemes, their biological importance and the adverse effects of FDA approved six-membered ring fused pyrimidine-based drugs. Covering all these aspects may lighten the researchers with the updated literature exploring the best synthetic routes and can think of alternative synthetic routes with less time consuming and non-toxic solvents. � 2023 Elsevier Ltd. All rights reserved.Item Synthetic strategies and pharmacological activities of chromene and its derivatives: An overview(Elsevier B.V., 2022-04-07T00:00:00) Katiyar, Madhurendra K.; Dhakad, Govind Kumar; Shivani; Arora, Sahil; Bhagat, Srikant; Arora, Taruna; Kumar, RajChromene is commonly found in nature and is considered one of the most frequently used scaffolds in heterocyclic chemistry for the designing of chemical probes for therapeutic and diagnostic purposes. The chromene nucleus comprises an oxine ring fused with a phenyl ring. Owing to existing several useful biological applications of chromenes have generated wide interest among chemists to synthesize its derivatives frequently. Here, in this review, we have compiled and analysed various recently reported synthetic strategies of chromene and its derivatives through numerous approaches such as microwave-assisted, catalyst based, green solvents, solvent-free conditions, etc. along with their biological applications such as anticancer, antimicrobial, anti-inflammatory, AChE inhibition, antiviral, and antioxidant activities. � 2022 Elsevier B.V.