Department Of Zoology

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Author: search.filters.author.Kaur, SukhchainHas files: No

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    Connecting the Link between Oxidative Stress, Dietary Antioxidants and Hypertension
    (CRC Press, 2023-06-12T00:00:00) Kaur, Sukhchain; Midha, Tushar; Dutta, Oyndril; Saini, Om Prakash; Muduli, Rasmi Ranjan; Mantha, Anil K.; Dhiman, Monisha
    Cardiovascular disorders such as hypertension, coronary heart disease (CHD), cerebrovascular disease, etc. accounts for millions of deaths per year and among these, hypertension (i.e. increased blood pressure) acts as a silent killer and is responsible for 7.5 billion deaths worldwide. Previously, abnormal functioning of the Renin Angiotensin Aldosterone System (RAAS) was considered as a risk factor for hypertension but in recent times, oxidative stress is a key factor in exaggerating the disease progression. In hypertension, oxidative stress damages the biomolecules, decreases the NO availability and endothelial functioning. The use of external antioxidants as therapeutic agents is an excellent approach in the treatment of hypertension. These antioxidants can reverse the deleterious effects of oxidative stress and recover normal cellular homeostasis. The book chapter is focused on the various natural antioxidants and their role as anti-hypertensive agents. � 2024 selection and editorial matter, Victor R. Preedy, Vinood B. Patel, and Rajkumar Rajendram.
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    Bioremediation: A favorable perspective to eliminate heavy metals from polluted soil
    (Elsevier, 2022-09-30T00:00:00) Kaur, Sukhchain; Midha, Tushar; Verma, Harkomal; Muduli, Rasmi Ranjan; Dutta, Oyindril; Saini, Omprakash; Prakash, Richa; Sharma, Sandeep; Mantha, Anil K.; Dhiman, Monisha
    The heavy metal contamination in the environment causes serious risk and long-term lethal effects to all living organisms due to their ability to show toxicity at low concentrations. The bio-magnification of heavy metals in the food chain is a matter of concern for public health. The persistent exposure to heavy metals such as mercury (Hg), lead (Pb), cadmium (Cd), arsenic (As), and uranium (U) cause several pathologic conditions in humans by interfering with normal cellular processes. Due to the non-biodegradable nature of these pollutants, they get accumulated for a long time in the soil. The removal of these pollutants by conventional methods is not satisfactory due to the high cost and generation of huge quantities of waste products. Hence, the use of micro-organisms is the most successful approach to remediate heavy metals from the environment due to their efficacy and financial viability. Numerous microorganisms have been employed to diminish the toxic effects of heavy metals. The combination of microorganisms and plants as a bioremediation strategy is another efficient method for heavy metal bioremediation. The chapter will summarize the heavy metal exploitation with a focus on Cd, As, Pb, and Chromium (Cr). It will also describe the various bioremediation techniques which are being used in the removal of these heavy metals from soil. � 2023 Elsevier Inc. All rights reserved.
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    Herbal Remedies for Improving Cancer Treatment Through Modulation of Redox Balance
    (Springer Singapore, 2022-09-28T00:00:00) Kaur, Sukhchain; Verma, Harkomal; Kaur, Sharanjot; Singh, Subham; Mantha, Anil K.; Dhiman, Monisha
    The redox modulation induced by oxidative stress is one of the major cause of the metabolic and inflammatory disorders including cancer. The reactive oxygen species (ROS) produced by various sources in the cell shift the redox homeostasis of cells towards more oxidizing or acidic environment. This shift results in the alterations of normal physiologic functioning of biomolecules as well as causes damage to these biomolecules (proteins, lipids, and DNA/RNA). The excessive ROS and redox modulation are the key factors that support growth, progression, and survival of cancer cells. ROS-induced redox modulation further activates pro-tumorigenic cellular pathways for e.g., PI3K/AKT, HIF-1, and MAPK signaling pathways as well as hinders epigenetic signaling. Increasing evidences demonstrate that long-term side effects of anti-cancer chemotherapy are major concern of medical sciences although modern treatments are quite effective. The combination of various herbal formulations with anti-cancer therapy shows improvement in treatment effectiveness in cancer patients. Bioactive compounds present in herbal formulations possess antioxidant and anti-cancer properties that help in the regulation of redox status of cancer cells. The synergetic effects of herbal remedies along with conventional treatment are proven as novel therapeutics in cancer progression management. Clinical studies have shown that broad range of herbs and bioactive compounds from various plants having antioxidant, anti-inflammatory properties can suppress the carcinogenesis. In this chapter we will discuss the role of various plants such as Glycyrrhiza glabra, Picrorhiza kurroa, Tinospora cordifolia, Curcuma longa, Ocimum sanctum, Viola odorata, and bioactive compound ferulic acid found in various cereals. The chapter will also focus on various mechanisms involved in the modulation of chemo-toxicity and improvement of efficacy of conventional anti-cancer therapies by these plants. � Springer Nature Singapore Pte Ltd. 2022.