School Of Basic And Applied Sciences

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Author: search.filters.author.Cho, Ssang-GooHas files: No

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    Bioactive peptides for boosting stem cell culture platform: Methods and applications
    (Elsevier Masson s.r.l., 2023-02-09T00:00:00) Abdal Dayem, Ahmed; Lee, Soo Bin; Lim, Kyung Min; Kim, Aram; Shin, Hyun Jin; Vellingiri, Balachandar; Kim, Young Bong; Cho, Ssang-Goo
    Peptides, short protein fragments, can emulate the functions of their full-length native counterparts. Peptides are considered potent recombinant protein alternatives due to their specificity, high stability, low production cost, and ability to be easily tailored and immobilized. Stem cell proliferation and differentiation processes are orchestrated by an intricate interaction between numerous growth factors and proteins and their target receptors and ligands. Various growth factors, functional proteins, and cellular matrix-derived peptides efficiently enhance stem cell adhesion, proliferation, and directed differentiation. For that, peptides can be immobilized on a culture plate or conjugated to scaffolds, such as hydrogels or synthetic matrices. In this review, we assess the applications of a variety of peptides in stem cell adhesion, culture, organoid assembly, proliferation, and differentiation, describing the shortcomings of recombinant proteins and their full-length counterparts. Furthermore, we discuss the challenges of peptide applications in stem cell culture and materials design, as well as provide a brief outlook on future directions to advance peptide applications in boosting stem cell quality and scalability for clinical applications in tissue regeneration. � 2023 The Authors
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    Role of Telomeres and Telomerase in Parkinson's Disease�A New Theranostics?
    (John Wiley and Sons Inc, 2023-08-21T00:00:00) Vellingiri, Balachandar; Balasubramani, Kiruthika; Iyer, Mahalaxmi; Raj, Neethu; Elangovan, Ajay; Song, Kwonwoo; Yeo, Han-Cheol; Jayakumar, Namitha; Kinoshita, Masako; Thangarasu, Ravimanickam; Narayanasamy, Arul; Dayem, Ahmed Abdal; Prajapati, Vijay Kumar; Gopalakrishnan, Abilash Valsala; Cho, Ssang-Goo
    Parkinson's disease (PD) is a complex condition that is significantly influenced by oxidative stress and inflammation. It is also suggested that telomere shortening (TS) is regulated by oxidative stress which leads to various diseases including age-related neurodegenerative diseases like PD. Thus, it is anticipated that PD would result in TS of peripheral blood mononuclear cells (PBMCs). Telomeres protect the ends of eukaryotic chromosomes preserving them against fusion and destruction. The TS is a normal process because DNA polymerase is unable to replicate the linear ends of the DNA due to end replication complications and telomerase activity in various cell types counteracts this process. PD is usually observed in the aged population and progresses over time therefore, disparities among telomere length in PBMCs of PD patients are recorded and it is still a question whether it has any useful role. Here, the likelihood of telomere attrition in PD and its implications concerning microglia activation, ageing, oxidative stress, and the significance of telomerase activators are addressed. Also, the possibility of telomeres and telomerase as a diagnostic and therapeutic biomarker in PD is discussed. � 2023 Wiley-VCH GmbH.