School Of Basic And Applied Sciences

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Author: search.filters.author.DeepikaSubject: search.filters.subject.sulfur insertion

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    DABCO Mediated Sulfur Activation-Intramolecular De-Nitration Strategy for the Synthesis of Novel Dihydrothiochromeno[4,3-c]pyrazoles
    (John Wiley and Sons Inc, 2023-07-24T00:00:00) Deepika; Paul, Avijit K.; Malakar, Chandi C.; Bansal, Ajay; Singh, Virender
    A facile and highly efficient metal-free approach has been unfolded for the synthesis of novel dihydrothiochromeno[4,3-c]pyrazoles using elemental sulfur as a powerful sulfurating reagent. This method includes sp2 C?H functionalization followed by sp2 C?NO2 group displacement using elemental sulfur as an odourless sulfur source activated by DABCO in DMSO. Using the developed synthetic strategy, a library of 29 novel dihydrothiochromeno[4,3-c]pyrazoles, incorporating two pharmacologically important scaffolds has been synthesized in 52�76% yield with a broad substrate scope. A sensible mechanistic proposal has been projected based on control experiments. � 2023 Wiley-VCH GmbH.
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    An efficient metal-free and catalyst-free C�S/C�O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides
    (Beilstein-Institut Zur Forderung der Chemischen Wissenschaften, 2023-03-02T00:00:00) Sharma, Shubham; Singh, Dharmender; Kumar, Sunit; Vaishali; Jamra, Rahul; Banyal, Naveen; Deepika; Malakar, Chandi C.; Singh, Virender
    An operationally simple and metal-free approach is described for the synthesis of pyrazole-tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary amines, and elemental sulfur in a single synthetic operation. The advantages of this developed protocol refer to the broad substrate scope, metal-free and easy to perform reaction conditions. Moreover, the pyrazole C-3/5-linked amide conjugates were also synthesized via an oxidative amination of pyrazole carbaldehydes and 2-aminopyridines using hydrogen peroxide as an oxidant. � 2023 Sharma et al.