School Of Basic And Applied Sciences

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Author: search.filters.author.Gill, Balraj SinghSubject: search.filters.subject.Ganoderma lucidum

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    Chemical profiling of ganoderma lucidum of bathinda region
    (Central University of Punjab, 2013) Gill, Balraj Singh; Kumar, Sanjeev
    Ganoderma lucidum is a basidiomycete's fungus with numerous pharmacological properties. The important ingredients of Ganoderma lucidum are terpenoids and polysaccharides etc. which play momentous role in immunomodulating, anti-inflammatory, anti-cancer, anti-diabetic and anti-oxidative. Mechanism of anticancer is still unrevealed. Aim of the present study was to analyse phytochemical difference in the Ganoderma lucidum growing on different hosts in Malwa region. Biomolecules play an imperative role in growth and development. Stress condition remodels the physiology, morphology and development of plant. To combat with stress, plants evolve with time and synthesize secondary metabolites. Stress tolerance ability is generated by overexpression of isoenzyme, intracellular targeting of anti-oxidants and overexpression ability of anti-oxidative enzyme. Ganoderma lucidum was analysed for different parameters such as total sugars, reducing sugars, starch, proteins, phenols, antioxidant property and flavonoids by standard procedures which was collected in different stages of development on different hosts, such as Azadirachta, Acacia, Bauhinia, Melia, and Dalbergia spp. It manifests fungus-host relationship and amount of phytoconstituent synthesized. The biochemical estimation showed 38.1±0.0481 g/100g of total sugars, 19±5.925 g/100g of reducing sugars, 57.3±3.333 g/100g of starch, 42±4.2% of proteins, 9.7±0.066% of phenols, 86.31%±5.480 scavenging activity in term of % inhibition and 5.26 ±0.6 mg/g of flavonoids. Complete analysis shows that except flavonoids all phytochemicals content was exceptionally high. Terpenoids analysis showed variation within the different hosts. Ganoderic acid, which is most active anticancerous molecule showed variation within different hosts. It can be concluded from the preliminary studies that there are variations in the chemical constituents of GL with change in host which makes it a "chemovariant"
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    Triterpenes in cancer: significance and their influence
    (Springer Netherlands, 2016) Gill, Balraj Singh; Kumar, Sanjeev; Navgeet
    Natural products are enriched with numerous compounds with a broad spectrum of therapeutics indication suggesting the role of functional moieties as a core pharmacophore. This review highlights the role of triterpene in targeting signaling pathways in cancer. Advancement in cellular, biochemical, experimental, and computational approaches provides new insights into various pathways in cancer. In signaling network, triterpenes primarily target membrane receptors which control and modulates expression level of the biological responses. Triterpenes are immunomodulatory targeting nuclear factor kappa B, toll-like receptors, signal transducer and activator of transcription 3, and PI3K/Akt/mTOR. Triterpenes isolated from plants and fungus mainly focus on the process of apoptosis while other signaling areas in the cancer are still shrouded. Some of the triterpenes have already passed the clinical trial, whereas many more have been proven to yield effective results. This review would help the researchers to study the role of triterpenes in cancer, thus, helping them to discover and design efficacious therapeutics agents. ? 2016, Springer Science+Business Media Dordrecht.
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    Misconstrued versatility of Ganoderma lucidum: a key player in multi-targeted cellular signaling
    (Springer, 2016) Gill, Balraj Singh; Sharma, Prateek; Kumar, Raj; Kumar, Sanjeev
    A Basidiomycetes fungus belonging to polypore family of mushrooms, Ganoderma lucidum (GL), has been known since a long time for their myriad therapeutic indications. Renowned as an invaluable resource of cardinal mycoconstituents they encompass numerous terpenoids polysaccharides and proteins. Possessing the therapeutically potent lanosteroidal skeleton, terpenoids are upheld for their invariable participation in therapeutically diverse bioactivities. Polysaccharides and proteins exhibiting distinguishable bioactivities provide this oriental mushroom with additional edges over immune function and anti-cancer potential. This review is a concerted effort to throw light upon the therapeutic versatility of the fungus, shadowed by various other natural products. An effort has been made towards conglomerating the mycoconstituents decisive for the many activities portrayed by this fungus. More importantly, this review seeks to fathom the inextricable role played by derivatives in modulating signaling cascades such as downregulation of various mitogenic pathways, inhibiting growth factors, or upregulating certain pathways enhancing cellular integrity.