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Trisodium citrate dihydrate catalyzed one-pot pseudo four-component synthesis of fully functionalized pyridine derivatives
(Taylor and Francis Ltd., 2022-07-22T00:00:00) Sharma, Aditi; Singh, Arvind; Priya, Anu; Kaur, Manmeet; Gupta, Vivek Kumar; Jaitak, Vikas; Banerjee, Bubun
A facile and convenient method has been developed for the one-pot pseudo-four component synthesis of fully functionalized pyridine derivatives from the reactions of aromatic aldehydes, malononitrile and thiols in the presence of a catalytic amount of trisodium citrate dihydrate as an efficient metal-free catalyst in aqueous ethanol under refluxed conditions. All the reactions were completed within just 45 minutes and the desired products afforded in excellent yields (90�95%). Gram scale production of the desired compound was also achieved. Synthesis of biologically promising scaffolds, high atom economy, excellent yields, use of metal-free catalyst, less toxic solvents, no column chromatographic purifications, reusability of the solvent media, multiple carbon-carbon and carbon-heteroatom bond formations are some of the major advantages of this newly developed protocol. � 2022 Taylor & Francis Group, LLC.