School Of Basic And Applied Sciences

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Author: search.filters.author.Kaur, J.Has files: No

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    Isolation, Characterization, and Quantification of a New Anticancer Constituent from Leaves of Nyctanthes arbor-tristis
    (Springer, 2022-05-03T00:00:00) Grover, P.; Kaur, J.; Suri, K.A.; Kumar, R.; Bansal, G.
    A new compound, 1,1,2-tris(2?,4?-di-tert-butylphenyl)-4,4-dimethylpent-1-ene, was isolated and characterized from the leaves of Nyctanthes arbor-tristis L. The plant was subjected to bioactivity-guided fractionation, and a compound was isolated from chloroform extract that was found to have potent anticancer activity. The chloroform extract was further fractionated, and a pure compound was isolated that was found to be active against three cancer cell lines (HL-60, HCT-116, and A-549). An RP-HPLC method was developed for quantification of the isolated compound. The content of the isolated compound was 0.88% in the chloroform extract and 0.08% in N. arbor-tristis leaves. � 2022, Springer Science+Business Media, LLC, part of Springer Nature.
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    On the flag curvature of a homogeneous Finsler space with generalized m-Kropina metric
    (Balkan Society of Geometers, 2022-03-01T00:00:00) Kaur, J.; Shanker, G.; Jangir, S.
    In this paper, first, we give an explicit formula for the flag curvature of a homogeneous Finsler space with generalized m-Kropina metric. Then, we show that, under a mild condition, the two definitions of naturally reductive homogeneous Finsler space are equivalent for aforesaid metric. Finally, we study the flag curvature of naturally reductive homogeneous Finsler spaces with generalized m-Kropina metric. � Balkan Society of Geometers, Geometry Balkan Press 2022.
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    In silico study of flavonoids as DPP-4 and α-glucosidase inhibitors
    (Bentham Science Publishers B.V., 2018) Kaur, J.; Singla, Ramit; Jaitak, Vikas
    Background: Diabetes being among the most prevalent disease is being studied widely to achieve most potent drug with lesser side-effects. Numerous targets have been explored and several drugs have been developed to combat type-2 diabetes. Worldwide scenario depicts an increase in the number of diabetics at an alarming rate. Due to this critical need in the current scenario, the focus has been shifted to natural products. Amongst which flavonoids have been extensively studied for their anti-diabetic potential. Among various targets inhibition of DPP-4, ?-glucosidase arose as an advantageous methodology for the management of type-2 diabetes. DPP-4 inhibitor helps to maintain the insulin levels in the body and ?-glucosidase inhibitor aids in the control of the postprandial glycemia. Methods: In the present study, the molecular modeling of 155 flavonoids has been performed using GLIDE against Dipeptidyl Peptidase-4 (DPP-4) (PDB ID:2ONC) and ?-glucosidase (PDB ID: 2QMJ) so as to achieve lead compounds that can be further used to develop a new drug. Results: Rutin and Theaflavin-3,3'-di-O-gallate were observed to possess the best docking score for ?-glucosidase and DPP-4 respectively. Conclusions: The top scoring flavonoids show promising results, but further studies are required to be carried out including the pharmacophore mapping, SAR and QSAR studies. The results illustrated that the hydrogen bonding plays a crucial role in the binding and positioning of the molecules into the active site. Further, the rescoring of the docking values mentioned as MMGB/SA also reconfirmed that these compounds show favorable results. ? 2018 Bentham Science Publishers.