School Of Basic And Applied Sciences

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Author: search.filters.author.Kaur, Manpreet

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    Seven-membered ring fused pyrimidine-based derivatives and their biological properties
    (Elsevier, 2022-10-14T00:00:00) Kaur, Manpreet; Kumar, Raj
    In the chapter, the synthesis along-with the biological importance of seven-membered ring fused pyrimidine-based derivatives has been discussed, where the seven-membered rings may consist of heteroatoms such as sulfur, oxygen, and nitrogen, which are supposed to provide important binding interactions within the binding pocket of certain receptors/enzymes like Epidermal growth factor receptor, HER, etc. � 2023 Elsevier Ltd. All rights reserved.
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    A Minireview on the Scope of Cadogan Cyclization Reactions Leading to Diverse Azaheterocycles
    (John Wiley and Sons Inc, 2022-04-01T00:00:00) Kaur, Manpreet; Kumar, Raj
    From the last two decades, Cadogan cyclization reaction is considered as one of the best routes for the preparation of various azaheterocycles comprising carbazoles, indoles, coumarins, carbolines, pyrazoloquinoxalines, S,N-heterotetracenes from the nitro-based substrates by using a variety of tetravalent phosphorus-based reagents. To date the majority of Cadogan reactions are found to be intramolecular reactions, however, interestingly, a case of intermolecular Cadogan reaction is also reported, resulting in the widening of the reaction scope for futuristic perspectives. We report the Cadogan cyclization reactions for the synthesis of azaheterocycles from 2018 to present according to multiple classes of chemical frameworks including its scope (FDA approved drugs), along with the possibilities and mechanistic developments for unexpected products. � 2022 Wiley-VCH GmbH.
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    Synthesis of 1,4-dihydropyrazolo[4,3-b]indoles via intramolecular C(sp2)-N bond formation involving nitrene insertion, DFT study and their anticancer assessment
    (Academic Press Inc., 2021-06-29T00:00:00) Kaur, Manpreet; Mehta, Vikrant; Abdullah Wani, Aabid; Arora, Sahil; Bharatam, Prasad V.; Sharon, Ashoke; Singh, Sandeep; Kumar, Raj
    We herein report a new synthetic route for a series of unreported 1,4-dihydropyrazolo[4,3-b]indoles (6�8) via deoxygenation of o-nitrophenyl-substituted N-aryl pyrazoles and subsequent intramolecular (sp2)-N bond formation under microwave irradiation expedite modified Cadogan condition. This method allows access to NH-free as well as N-substituted fused indoles. DFT study and controlled experiments highlighted the role of nitrene insertion as one of the plausible reaction mechanisms. Furthermore, the target compounds exhibited cytotoxicity at low micromolar concentration against lung (A549), colon (HCT-116), and breast (MDA-MB-231, and MCF-7) cancer cell lines, induced the ROS generation and altered the mitochondrial membrane potential of highly aggressive MDA-MB-231 cells. Further investigations revealed that these compounds were selective Topo I (6h) or Topo II (7a, 7b) inhibitors. � 2021 Elsevier Inc.
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    Dynamic Axial Chirality in Drug Design and Discovery: Introduction to Atropisomerism, Classification, Significance, Recent Trends and Challenges
    (Springer Singapore, 2021-02-18T00:00:00) Joshi, Gaurav; Kaur, Manpreet; Kumar, Raj
    Induction of chirality in non-chiral ligands via involvement of hindered rotation around a single bond has led to the development of atropisomers. The atropisomers behave similarly as the chiral compounds and impact the drug discovery process. The chapter deals importantly with the brief introduction to this class, nomenclature descriptors, methods to measure atropisomers racemization, and the impact of atropisomers on drug discovery and includes relevant examples of drugs both from synthetic and natural origin. The chapter further extends to deal with various methodologies involved in atropselective conversions and regulatory guidelines involved in the development of atropisomers. � Springer Nature Singapore Pte Ltd. 2021.
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    Efficient synthesis and mechanistic insights for the formation of imidazo[1,2-a]pyridines via multicomponent decarboxylative coupling using chitosan-supported copper catalysts
    (Elsevier B.V., 2023-10-03T00:00:00) Kaur, Pavneet; Gurjar, Kamlesh K.; Arora, Tania; Bharti, Divya; Kaur, Manpreet; Kumar, Vinod; Parkash, Jyoti; Kumar, Rakesh
    An efficient multicomponent decarboxylative coupling of 2-aminopyridines, aldehydes and alkynoic acids for the synthesis of imidazo[1,2-a]pyridines was developed using recyclable chitosan-supported copper (chit@CuSO4) as a heterogeneous catalyst. Computational and experimental evidence revealed that in situ generated propargylamine undergoes cyclization to the desired imidazopyridine via prototropic isomerization involving allene type intermediates. Control experiments on isolated propargylamine demonstrated that cyclization could proceed without any metal catalyst. In literature, the cyclization step is assumed to be facilitated by metal catalyst and experimental proof for the involvement of actual intermediates is not available. The synthesized imidazopyridines were further evaluated for antiproliferative activity against human neuroblastoma cells (SHSY-5Y) using MTT assay. � 2023 Elsevier B.V.
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    Seaweed-associated epiphytic bacteria: Diversity, ecological and economic implications
    (Elsevier B.V., 2023-07-18T00:00:00) Kaur, Manpreet; Saini, Khem Chand; Mallick, Ashrumochan; Bast, Felix
    The microbial communities associated with seaweeds remain underexplored, despite their enormous biodiversity and the fact that they differ significantly from their free-living marinecounterpart. Studying the epiphytic bacterial microbiota, directly or indirectly, plays a vital role in normal algal morphological development, metabolism, growth and defence against fouling organisms. Furthermore, as these bacteria interact with algae in multifaceted ways, they constitute a fascinating source of new bioactive compounds with antimicrobials, antibiotic potential and produce algal-specific polysaccharidases with biotechnological applications. Microscopy, accompanied by bacterial culture and molecular biology, has made it feasible to establish and identify the phylogenetic origin of various algae-associated bacterial communities. Thus, this review first highlights the immense diversity of the epiphytic bacteria associated with algae, predominantly from the phyla Proteobacteria, Bacteroidetes, and Firmicutes. We further describe the factors affecting the composition and abundance of the epiphytic bacteria and their ecological role. We end with the bioprospecting value of this interaction, such as the production of hydrolytic enzymes and specific bioactive compounds. However, further investigation of the epiphytic bacterial communities present in different macroalgae using new technologies is still needed, mainly to evaluate the production of various metabolites with biotechnologicalapplications. � 2023 Elsevier B.V.
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    Concise review of green algal genus Monostroma Thuret
    (Springer Science and Business Media B.V., 2022-10-27T00:00:00) Kaur, Manpreet; Kala, Swarna; Parida, Aseema; Bast, Felix
    Monostroma (Ulotrichales, Chlorophyta) is the most intensively cultivated genus among green seaweeds, accounting for over 90% of total green algal cultivation. It is commonly found in the eulittoral zones of marine and estuarine habitats, thus contributing significantly to the ecology of the coastal ecosystem. Morphologically, the frond of Monostroma is blade-like with eponymous one-cell thickness; therefore, it is also known as �Slender sea lettuce�. Monostroma nitidum is often used for salad ingredients, boiled tsukudani, soups, etc., due to its health benefits. Monostroma kuroshiense is commercially cultivated in�East Asia�and�South America�for the edible product "hitoegusa-nori" or "hirohano-hitoegusa nori", popular�sushi�wraps. This genus remains one of the well-studied seaweed genera for ecophysiology, habitat-dependent seasonality of its growth pattern, gametangial ontogeny and phylogenetics. Moreover, rhamnan sulfate (RS), a sulfated polysaccharide, is the main component of the fiber extracted from�M. nitidum and studied for various biological activities. This review presents the taxonomy, morphology, anatomy, life history, distribution, ecology, physiology, cultivation and harvesting, chemical composition, and biotechnological applications of this genus. � 2022, The Author(s), under exclusive licence to Springer Nature B.V.
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    Abiotic stress in algae: response, signaling and transgenic approaches
    (Springer Science and Business Media B.V., 2022-05-02T00:00:00) Kaur, Manpreet; Saini, Khem Chand; Ojah, Hiramoni; Sahoo, Rajalakshmi; Gupta, Kriti; Kumar, Adesh; Bast, Felix
    High salinity, nutrient deficiency, heavy metals, desiccation, temperature fluctuations, and ultraviolet radiations are major abiotic stress factors considered inhospitable to algal growth and development in natural and artificial environments. All these stressful conditions cause effects on algal physiology and thus biochemical functioning. For instance, long-term exposure to hyper/hypo salinity conditions inhibits cell differentiation and reduces growth. Photosynthesis is completely blocked in algae's dehydrated state, resulting in photoinhibition or photodamage. The limitation of nutrients in aquatic environments inhibits primary production via regulating phytoplankton community development and structure. Hence, in response to these stressful conditions, algae develop plenty of cellular, physiological, and morphological defences to survive and thrive. The conserved and generalized defence responses in algae include the production of secondary metabolites, desaturation of membrane lipids, activation of reactive species scavengers, and accumulation of compatible solutes. Moreover, a well-coordinated and timely response to such stresses involves signal perception and transduction mainly via phytohormones that could sustain algae growth under abiotic stress conditions. In addition, the combination of abiotic stresses and plant hormones could further elevate the biosynthesis of metabolites and enhance the ability of algae to tolerate abiotic stresses. This review aims to present different kinds of stressful conditions confronted by algae and their physiological and biochemical responses, the role of phytohormones in combatting these conditions, and, last, the future transgenic approaches for improving abiotic stress tolerance in algae. � 2022, The Author(s), under exclusive licence to Springer Nature B.V.
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    Lychee Wastes and By-Products: Chemistry, Processing, and Utilization
    (CRC Press, 2022-08-05T00:00:00) Kaur, Gurwinder; Singh, Barinderjit; Srivastava, Yashi; Kaur, Manpreet; Gat, Yogesh
    Lychee (Lychee chinensis) is a tropical or subtropical fruit commonly grown in Asian countries. All parts of lychee are rich in protein, fat, carbohydrates, vitamins (ascorbic acid, thiamine, riboflavin, niacin), minerals (potassium, nitrogen, phosphorus, calcium, magnesium, sodium, iron) and bioactive components like phenolic acids, flavonoids, lignans, carotenoids, sesquiterpenes and sterols. Wastes and by-products (seed, peel and pomace) obtained during processing of lychee has great potential for utilization in the production of peel flour, chutney, wine, enzymes, antioxidant agents, coloring agents, bioethanol, biogas, and biochar. The lychee fruit residues have enormous potential use like used as a dyeing agent, microbiological culture medium and corrosion-resistant material. � 2023 selection and editorial matter, Khalid Muzaffar, Sajad Ahmad Sof, and Shabir Ahmad Mir, individual chapters, the contributors.
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    Seaweed-associated epiphytic bacteria: Diversity, ecological and economic implications
    (Elsevier B.V., 2023-07-18T00:00:00) Kaur, Manpreet; Saini, Khem Chand; Mallick, Ashrumochan; Bast, Felix
    The microbial communities associated with seaweeds remain underexplored, despite their enormous biodiversity and the fact that they differ significantly from their free-living marinecounterpart. Studying the epiphytic bacterial microbiota, directly or indirectly, plays a vital role in normal algal morphological development, metabolism, growth and defence against fouling organisms. Furthermore, as these bacteria interact with algae in multifaceted ways, they constitute a fascinating source of new bioactive compounds with antimicrobials, antibiotic potential and produce algal-specific polysaccharidases with biotechnological applications. Microscopy, accompanied by bacterial culture and molecular biology, has made it feasible to establish and identify the phylogenetic origin of various algae-associated bacterial communities. Thus, this review first highlights the immense diversity of the epiphytic bacteria associated with algae, predominantly from the phyla Proteobacteria, Bacteroidetes, and Firmicutes. We further describe the factors affecting the composition and abundance of the epiphytic bacteria and their ecological role. We end with the bioprospecting value of this interaction, such as the production of hydrolytic enzymes and specific bioactive compounds. However, further investigation of the epiphytic bacterial communities present in different macroalgae using new technologies is still needed, mainly to evaluate the production of various metabolites with biotechnologicalapplications. � 2023 Elsevier B.V.