School Of Basic And Applied Sciences

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Author: search.filters.author.Kumar, AmitHas files: Yes

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    Natural products as multidrug resistance modulators in cancer
    (Elsevier, 2019) Kumar, Amit; Jaitak, Vikas
    Cancer is a prominent cause of death globally. Currently, many drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Risk of tumors acquiring resistance to chemotherapy (multidrug resistance) remains a significant hurdle to the successful treatment of various types of cancer. Membrane-embedded drug transporters, generally overexpressed in cancer, are the leading cause among multiple mechanisms of multidrug resistance (MDR). P-glycoprotein (P-gp) also MDR1/ABCB1, multidrug resistance associated protein 1 (MRP1/ABCC1), MRP2 and breast cancer resistance protein (BCRP/ABCG2) are considered to be a prime factor for induction of MDR. To date, several chemical substances have been tested in a number of clinical trials for their MDR modulatory activity which are not having devoid of any side effects that necessitates to find newer and safer way to tackle the current problem of multidrug resistance in cancer. The present study systematically discusses the various classes of natural products i.e flavonoids, alkaloids, terpenoids, coumarins (from plants, marine, and microorganisms) as potential MDR modulators and/or as a source of promising lead compounds. Recently a bisbenzyl isoquinoline alkaloid namely tetrandrine, isolated from Chinese herb Stephania tetrandra (Han-Fang-Chi) is in clinical trials for its MDR reversal activity. © 2019 Elsevier Masson SAS
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    Optimal way of selecting cities and conveyances for supplying coal in uncertain environment
    (Springer India, 2014) Kumar, Amit; Kaur, Amarpreet
    In this paper, the limitations and shortcomings of the existing methods for solving fuzzy solid transportation problem are pointed out and to overcome these shortcomings, a new method is proposed for solving fuzzy solid transportation problem. The advantages of the proposed method over the existing methods are discussed. To illustrate the proposed method, an existing fuzzy solid transportation problem is solved. Also, to show the application of the proposed method in real life problems an existing real life fuzzy solid transportation problem is solved by the proposed method. ? 2014 Indian Academy of Sciences.
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    A note on "A fuzzy approach to transport optimization problem"
    (Springer New York LLC, 2016) Sidhu, Sukhpreet Kaur; Kumar, Amit; Kaur, Amarpreet
    Sudhagar and Ganesan (Optim Eng, 2012, doi:10.1007/s11081-012-9202-6) proposed an approach to find the fuzzy optimal solution of such fuzzy transportation problems in which all the parameters are represented by fuzzy numbers. In this note, it is pointed out that the authors have used some mathematical incorrect assumptions in their proposed method. ? 2015, Springer Science+Business Media New York.