School Of Basic And Applied Sciences

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Author: search.filters.author.Kumar, Mohit

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    Environmental Friendly Technologies for Remediation of Toxic Heavy Metals: Pragmatic Approaches for Environmental Management
    (Springer International Publishing, 2022-05-06T00:00:00) Sharma, Ritika; Saini, Khem Chand; Rajput, Sneh; Kumar, Mohit; Mehariya, Sanjeet; Karthikeyan, Obulisamy Parthiba; Bast, Felix
    Contamination of different environmental matrices (air, soil, and water) by toxic heavy metals is a widespread problem that disturbs the environment as an outcome of many anthropocentric practices. Heavy metals exceeding the permissible limits exert deleterious impacts on human beings, causing life-threatening health manifestations and detrimental effects on the environment. This has alarmed the dire need to explore various modern remediation techniques that can be utilized to lower excessive concentrations. Owing to their high-cost effectiveness, unsatisfactory output, environmentally unfriendly, complicated procedure, and high operational costs, these technologies failed to find any practical utility in remediation. On the other hand, plants and associated microorganisms are receiving more consideration as a means of remediating or degrading environmental pollutants. This chapter provides us insights into the various environmental friendly techniques that will improve our environment�s quality. Among which, phytoremediation is considered an effective technique which is known for its esthetic benefits and endless applicability. Furthermore, metal-resistant bacteria (plant growth-promoting rhizobacteria) are also reported to play a pivotal role in the phytoremediation and solubilization of minerals. Thus, this chapter critically reviews the phytoremediation technology and the efficient exploitation of microbes to alleviate the environmental burden of toxic heavy metals. � The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
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    Environmental Friendly Technologies for Remediation of Toxic Heavy Metals: Pragmatic Approaches for Environmental Management
    (Springer International Publishing, 2022-05-06T00:00:00) Sharma, Ritika; Saini, Khem Chand; Rajput, Sneh; Kumar, Mohit; Mehariya, Sanjeet; Karthikeyan, Obulisamy Parthiba; Bast, Felix
    Contamination of different environmental matrices (air, soil, and water) by toxic heavy metals is a widespread problem that disturbs the environment as an outcome of many anthropocentric practices. Heavy metals exceeding the permissible limits exert deleterious impacts on human beings, causing life-threatening health manifestations and detrimental effects on the environment. This has alarmed the dire need to explore various modern remediation techniques that can be utilized to lower excessive concentrations. Owing to their high-cost effectiveness, unsatisfactory output, environmentally unfriendly, complicated procedure, and high operational costs, these technologies failed to find any practical utility in remediation. On the other hand, plants and associated microorganisms are receiving more consideration as a means of remediating or degrading environmental pollutants. This chapter provides us insights into the various environmental friendly techniques that will improve our environment�s quality. Among which, phytoremediation is considered an effective technique which is known for its esthetic benefits and endless applicability. Furthermore, metal-resistant bacteria (plant growth-promoting rhizobacteria) are also reported to play a pivotal role in the phytoremediation and solubilization of minerals. Thus, this chapter critically reviews the phytoremediation technology and the efficient exploitation of microbes to alleviate the environmental burden of toxic heavy metals. � The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
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    Synthesis, Biological Evaluation and Molecular Modeling Studies of Propargyl‐Containing 2,4,6‐Trisubstituted Pyrimidine Derivatives as Potential Anti‐Parkinson Agents
    (Wiley, 2018) Kumar, Bhupinder; Kumar, Mohit; Dwivedi, Ashish Ranjan; Kumar, Vinod
    Monoamine oxidase B (MAO‐B) inhibitors are potential drug candidates for the treatment of various neurological disorders including Parkinson's disease. A total of 20 new propargyl‐containing 2,4,6‐trisubstituted pyrimidine derivatives were synthesized and screened for MAO inhibition using Amplex Red assays. All the synthesized compounds were found to be reversible and selective inhibitors of the MAO‐B isoform at sub‐micromolar concentrations. MVB3 was the most potent MAO‐B inhibitor with an IC50 value of 0.38±0.02 μμ, whereas MVB6 (IC50=0.51±0.04 μμ) and MVB16 (IC50=0.48±0.06 μμ) were the most selective for MAO‐B with a selectivity index of more than 100‐fold. In cytotoxic studies, these compounds were found to be nontoxic to human neuroblastoma SH‐SY5Y cells at concentrations of 25 μm. MVB6 was found to decrease the intracellular level of reactive oxygen species to 68 % at 10 μm concentration, whereas other compounds did not produce significant changes in reactive oxygen species levels. In molecular modeling studies, MVB3 displayed strong binding affinity for the MAO‐B isoform with a dock score of −10.45, in agreement with the observed activity. All the compounds fitted well in the hydrophobic cavity of MAO‐B. Thus, propargyl‐substituted pyrimidine derivatives can be promising leads in the development of potent, selective and reversible MAO‐B inhibitors for the treatment of Parkinson's disease.