School Of Basic And Applied Sciences

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Author: search.filters.author.Kumar, Roshan

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    Precisely designed oxazolonaphthoimidazo[1,2-a]pyridine-based sensor for the detection of Fe3+ and DCP with cell imaging application
    (Elsevier B.V., 2023-05-17T00:00:00) Kathuria, Vishal; Kiran; Rani, Payal; Mayank; Joshi, Gaurav; Kumar, Roshan; Sindhu, Jayant; Kumar, Parvin; Negi, Arvind; Kumar, Sudhir
    Two new turn-off fluorescent sensors (V3 and V4) presented in the article revealed the potential application for the precise detection of Fe3+ and diethylchlorophosphate (DCP). These sensors include oxazolonaphthoimidazo[1,2-a]pyridine scaffold integrated with anthracene and pyrene-based framework. This design has facilitated the twisted intramolecular charge transfer (TICT) and planarised intramolecular charge transfer (PLICT) mechanisms, which were confirmed using computational and photophysical studies. The V3 and V4 fluorescent probes were particularly sensitive and highly selective for detecting Fe3+ and DCP analytes. For Fe3+, V3 and V4 undergo turn-off mechanism with the detection limit of 14.1 and 4.5 nM, respectively. Intracellular detection of Fe3+ via confocal live cell imaging was also demonstrated, showing its application under intracellular conditions. Our experimental data revealed the promises of V3 and V4 for instantaneous, accurate and on-spot monitoring of Fe3+ and DCP, even in the presence of other interfering analytes. � 2023 Elsevier B.V.
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    Precisely designed oxazolonaphthoimidazo[1,2-a]pyridine-based sensor for the detection of Fe3+ and DCP with cell imaging application
    (Elsevier B.V., 2023-05-17T00:00:00) Kathuria, Vishal; Kiran; Rani, Payal; Mayank; Joshi, Gaurav; Kumar, Roshan; Sindhu, Jayant; Kumar, Parvin; Negi, Arvind; Kumar, Sudhir
    Two new turn-off fluorescent sensors (V3 and V4) presented in the article revealed the potential application for the precise detection of Fe3+ and diethylchlorophosphate (DCP). These sensors include oxazolonaphthoimidazo[1,2-a]pyridine scaffold integrated with anthracene and pyrene-based framework. This design has facilitated the twisted intramolecular charge transfer (TICT) and planarised intramolecular charge transfer (PLICT) mechanisms, which were confirmed using computational and photophysical studies. The V3 and V4 fluorescent probes were particularly sensitive and highly selective for detecting Fe3+ and DCP analytes. For Fe3+, V3 and V4 undergo turn-off mechanism with the detection limit of 14.1 and 4.5 nM, respectively. Intracellular detection of Fe3+ via confocal live cell imaging was also demonstrated, showing its application under intracellular conditions. Our experimental data revealed the promises of V3 and V4 for instantaneous, accurate and on-spot monitoring of Fe3+ and DCP, even in the presence of other interfering analytes. � 2023 Elsevier B.V.
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    Microbial-based inoculants in sustainable agriculture: Current perspectives and future prospects
    (Elsevier, 2021-03-26T00:00:00) Dukare, Ajinath; Paul, Sangeeta; Kumar, Roshan; Sharma, Vikas
    The incessant use of agrochemicals for improved soil fertility and plant productivity has caused negative environmental impacts, including contamination of soil, groundwater, and aquifers. Hence, eco-friendly methods of plant and soil nutrient management are required to maintain sustained crop productivity and ecological stability. Beneficial microbial inoculants are potential elements of such management approaches. With the latest studies, this chapter summarizes the efforts in using beneficial microbes including plant growth-promoting rhizobacteria and mycorrhizal fungi for improving plant growth and its nutritional quality in a sustained manner. Studies with many microbial inoculants have demonstrated their beneficial role in plant growth through effective root colonization and induction of plant growth support mechanisms. Direct plant growth support by root associated microbes is mediated through enhanced nutrient acquisition and hormonal activation. Numerous antifungal activities of microbes, associated with pathogen inhibition, are usually linked to providing superior plant growth. Some inoculants have been found useful in abiotic stress alleviation and nutritional fortification of edible crops. The use of modern scientific advances for improving performances of microbial inoculants under stressed agriculture is also gaining scientific attention. Overall, the exploitation of beneficial microorganisms and their useful interactions with plants offer promising and eco-friendly strategies in the development of organic agriculture globally. � 2021 Elsevier Inc. All rights reserved.
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    Microbial-based inoculants in sustainable agriculture: Current perspectives and future prospects
    (Elsevier, 2021-03-26T00:00:00) Dukare, Ajinath; Paul, Sangeeta; Kumar, Roshan; Sharma, Vikas
    The incessant use of agrochemicals for improved soil fertility and plant productivity has caused negative environmental impacts, including contamination of soil, groundwater, and aquifers. Hence, eco-friendly methods of plant and soil nutrient management are required to maintain sustained crop productivity and ecological stability. Beneficial microbial inoculants are potential elements of such management approaches. With the latest studies, this chapter summarizes the efforts in using beneficial microbes including plant growth-promoting rhizobacteria and mycorrhizal fungi for improving plant growth and its nutritional quality in a sustained manner. Studies with many microbial inoculants have demonstrated their beneficial role in plant growth through effective root colonization and induction of plant growth support mechanisms. Direct plant growth support by root associated microbes is mediated through enhanced nutrient acquisition and hormonal activation. Numerous antifungal activities of microbes, associated with pathogen inhibition, are usually linked to providing superior plant growth. Some inoculants have been found useful in abiotic stress alleviation and nutritional fortification of edible crops. The use of modern scientific advances for improving performances of microbial inoculants under stressed agriculture is also gaining scientific attention. Overall, the exploitation of beneficial microorganisms and their useful interactions with plants offer promising and eco-friendly strategies in the development of organic agriculture globally. � 2021 Elsevier Inc. All rights reserved.