School Of Basic And Applied Sciences

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    A brief overview of potential treatments for viral diseases using natural plant compounds: The case of sars-cov
    (MDPI AG, 2021-06-24T00:00:00) Abiri, Rambod; Abdul-Hamid, Hazandy; Sytar, Oksana; Abiri, Ramin; de Almeida, Eduardo Bezerra; Sharma, Surender K.; Bulgakov, Victor P.; Arroo, Randolph R. J.; Malik, Sonia
    The COVID-19 pandemic, as well as the more general global increase in viral diseases, has led researchers to look to the plant kingdom as a potential source for antiviral compounds. Since ancient times, herbal medicines have been extensively applied in the treatment and prevention of various infectious diseases in different traditional systems. The purpose of this review is to highlight the potential antiviral activity of plant compounds as effective and reliable agents against viral infections, especially by viruses from the coronavirus group. Various antiviral mechanisms shown by crude plant extracts and plant-derived bioactive compounds are discussed. The understanding of the action mechanisms of complex plant extract and isolated plant-derived compounds will help pave the way towards the combat of this life-threatening disease. Further, molecular docking studies, in silico analyses of extracted compounds, and future prospects are included. The in vitro production of antiviral chemical compounds from plants using molecular pharming is also considered. Notably, hairy root cultures represent a promising and sustainable way to obtain a range of biologically active compounds that may be applied in the development of novel antiviral agents. � 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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    Seaweed-associated epiphytic bacteria: Diversity, ecological and economic implications
    (Elsevier B.V., 2023-07-18T00:00:00) Kaur, Manpreet; Saini, Khem Chand; Mallick, Ashrumochan; Bast, Felix
    The microbial communities associated with seaweeds remain underexplored, despite their enormous biodiversity and the fact that they differ significantly from their free-living marinecounterpart. Studying the epiphytic bacterial microbiota, directly or indirectly, plays a vital role in normal algal morphological development, metabolism, growth and defence against fouling organisms. Furthermore, as these bacteria interact with algae in multifaceted ways, they constitute a fascinating source of new bioactive compounds with antimicrobials, antibiotic potential and produce algal-specific polysaccharidases with biotechnological applications. Microscopy, accompanied by bacterial culture and molecular biology, has made it feasible to establish and identify the phylogenetic origin of various algae-associated bacterial communities. Thus, this review first highlights the immense diversity of the epiphytic bacteria associated with algae, predominantly from the phyla Proteobacteria, Bacteroidetes, and Firmicutes. We further describe the factors affecting the composition and abundance of the epiphytic bacteria and their ecological role. We end with the bioprospecting value of this interaction, such as the production of hydrolytic enzymes and specific bioactive compounds. However, further investigation of the epiphytic bacterial communities present in different macroalgae using new technologies is still needed, mainly to evaluate the production of various metabolites with biotechnologicalapplications. � 2023 Elsevier B.V.
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    Role of plant-based bioactive nutritional or dietary supplements in the metabolic syndrome of women and children during Covid-19
    (Apple Academic Press, 2023-08-04T00:00:00) Yashi, Srivastava; Awasthi, Ankit
    Metabolic syndrome includes obesity, type 2 diabetes (T2D) mellitus, hypertension, dyslipidemia, and inflammation showing detrimental result in women and children on the immune response to COVID-19. The plants are the best sources for the production of bioactive compounds like polyphenol, flavonoids, etc. (Keservani and Sharma, 2014). These compounds have properties to improve the functionality of many receptors (insulin IR, AMPK, TNF, and TNFR, cytokine receptor, IL-1, ILR, TNF, TNFR, and PPARG) that can control internal factors (LDL, VLDL, HDL, triglycerides, glucose level, C-reactive protein (CRP), erythrocytes, heart rate and blood pressure) which eventually reduces the risk of metabolic syndrome. The processing, digestibility, and functionality of bioactive constituents from plants helps in the consumption of nutraceutical supplements through many government schemes and decreases the cases of metabolic syndrome in many countries. � 2023 Apple Academic Press, Inc.
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    Seaweed-associated epiphytic bacteria: Diversity, ecological and economic implications
    (Elsevier B.V., 2023-07-18T00:00:00) Kaur, Manpreet; Saini, Khem Chand; Mallick, Ashrumochan; Bast, Felix
    The microbial communities associated with seaweeds remain underexplored, despite their enormous biodiversity and the fact that they differ significantly from their free-living marinecounterpart. Studying the epiphytic bacterial microbiota, directly or indirectly, plays a vital role in normal algal morphological development, metabolism, growth and defence against fouling organisms. Furthermore, as these bacteria interact with algae in multifaceted ways, they constitute a fascinating source of new bioactive compounds with antimicrobials, antibiotic potential and produce algal-specific polysaccharidases with biotechnological applications. Microscopy, accompanied by bacterial culture and molecular biology, has made it feasible to establish and identify the phylogenetic origin of various algae-associated bacterial communities. Thus, this review first highlights the immense diversity of the epiphytic bacteria associated with algae, predominantly from the phyla Proteobacteria, Bacteroidetes, and Firmicutes. We further describe the factors affecting the composition and abundance of the epiphytic bacteria and their ecological role. We end with the bioprospecting value of this interaction, such as the production of hydrolytic enzymes and specific bioactive compounds. However, further investigation of the epiphytic bacterial communities present in different macroalgae using new technologies is still needed, mainly to evaluate the production of various metabolites with biotechnologicalapplications. � 2023 Elsevier B.V.
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    Role of plant-based bioactive nutritional or dietary supplements in the metabolic syndrome of women and children during Covid-19
    (Apple Academic Press, 2023-08-04T00:00:00) Yashi, Srivastava; Awasthi, Ankit
    Metabolic syndrome includes obesity, type 2 diabetes (T2D) mellitus, hypertension, dyslipidemia, and inflammation showing detrimental result in women and children on the immune response to COVID-19. The plants are the best sources for the production of bioactive compounds like polyphenol, flavonoids, etc. (Keservani and Sharma, 2014). These compounds have properties to improve the functionality of many receptors (insulin IR, AMPK, TNF, and TNFR, cytokine receptor, IL-1, ILR, TNF, TNFR, and PPARG) that can control internal factors (LDL, VLDL, HDL, triglycerides, glucose level, C-reactive protein (CRP), erythrocytes, heart rate and blood pressure) which eventually reduces the risk of metabolic syndrome. The processing, digestibility, and functionality of bioactive constituents from plants helps in the consumption of nutraceutical supplements through many government schemes and decreases the cases of metabolic syndrome in many countries. � 2023 Apple Academic Press, Inc.