School Of Basic And Applied Sciences

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    A review on challenges to remedies of MnO2 based transition-metal oxide, hydroxide, and layered double hydroxide composites for supercapacitor applications
    (Elsevier Ltd, 2022-07-16T00:00:00) Kour, Simran; Tanwar, Shweta; Sharma, A.L.
    Supercapacitors are emerging energy storage devices admired in the research field due to their tremendous electrochemical properties parameters. Few peculiar properties parameters such as- high capacitance, large specific power/energy, excellent cyclic life, and rapid charging/discharging make them superior to other existing energy storage/conversion systems. Supercapacitors are predicted to be the potential energy resources for vast number of applications ranging from heavy electric vehicles to portable electrical/personal electronic appliances due to their ultra-fast charging behavior. The working efficiency of any supercapacitor is generally reliant on chosen materials acting as an electrode. In electrode materials series, manganese dioxide (MnO2) has been mostly explored and proven to be very effective and promising material as supercapacitor electrode. This is attributable to its superior theoretical capacitance, environmental friendliness, lower price, and vast profusion. But its deprived electrical conductivity and the volume expansion restrict its practical utility as a preferred electrode material. To make full utility of MnO2 materials, its composites with different type of materials have been tried and tested. The most fascinating composite electrode materials with MnO2 are discussed here in detail. The composites discussed in detail are MnO2/Transition metal oxides, MnO2/Transition metal hydroxides, and MnO2/Layered double hydroxides. A complete overview of these composites has been given and finally the recommendation of the best composites has been figured out systematically. The new opportunities for the future towards the advancement of MnO2 based composites are also being highlighted. � 2022 Elsevier Ltd
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    Identification of miRNAs and related hub genes associated with the triple negative breast cancer using integrated bioinformatics analysis and in vitro approach
    (Taylor and Francis Ltd., 2021-08-13T00:00:00) Shuaib, Mohd; Prajapati, Kumari Sunita; Singh, Atul Kumar; Kushwaha, Prem Prakash; Waseem, Mohammad; Kumar, Shashank
    Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype generally associated with younger women. Due to the lack of suitable drugable targets in TNBC, the microRNAs are considered as a better hope as therapeutic agents for the management of the disease. In this study, we identified differentially expressed miRNAs (DEMs) and associated hub genes in TNBC microarray data (GSE38167, GSE60714, and GSE10833) using bioinformatics tools. The identified miRNAs and genes were validated in the TNBC cell line model (MDA-MB-231) compared with the normal breast cells (MCF-10A) using the qRT-PCR technique. False-positive DEMs were avoided by comparing the DEMs profile of TNBC and triple positive breast cancer (TPBC) cell line model (BT474) compared with the MCF-10A cells data. In addition, we studied the effect of anticancer phytochemicals on the differential expression of miRNAs and genes in MDA-MB-231 cells. Furthermore, target predictions, functional enrichment and KEGG pathway analysis, mutation and copy number alterations, and overall survival analysis of DEMs in TNBC sample was investigated using standard computational tools. The study identifies first time the association of hsa-miR-1250, has-miR-1273, and has-miR-635 with the TNBC. DEMs showed significant association with the Wnt, ErbB, PI3-Akt and cAMP signaling pathways having clinical implications in TNBC tumorigenesis. The DEMs and hub genes (HOXC6 and ACVR2B) showed survival disadvantages in TNBC patients. In summary, the identified miRNAs and hub genes show important implications in TNBC tumorigenesis and patient survival. We recommend further experimental studies on pathophysiological mechanism of the identified miRNAs and hub genes in TNBC. Communicated by Ramaswamy H. Sarma. � 2021 Informa UK Limited, trading as Taylor & Francis Group.