School Of Basic And Applied Sciences

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    Impact of Covid-19 outbreak on stress and depression among Indian football players; [Impacto del brote de Covid-19 en el estr�s y la depresi�n de futbolistas indios]
    (Universidad de Murcia, 2023-06-13T00:00:00) Cherappurath, Nafih; Ahmed, Md. Dilsad; L�pez S�nchez, Guillermo F.; Begum, Shaheen; Sreelekha, N.; Elayaraja, M.; Rathnayaka, Anoma; Kabeer, Dilshith Azeezul
    The Coronavirus-19 (COVID-19) pandemic restricted our normal life activities for the past several months, continuing its impact. Its repercussions led many countries to remain locked down and closed institutions and workplaces. The closure severely impacted the sporting industry and hindered performing its normal activities. Sports and exercise are generally considered the best facilitator for embedding a healthy and active lifestyle and were not adequately advocated during the pandemic. This study aimed to examine the level of stress and depression among football players during the peak time of the Covid-19 outbreak. Furthermore, it measured whether the socio-demographic information, such as gender, region, and level of participation influenced participants' stress and depression during that time. A total of 204 football players recruited from different parts of India participated in this study. Participants� responses to stress and depression were measured through the Perceived Stress Scale (PSS) and the Patient Health Questionnaire (PHQ-9). Stress and depression showed a significant correlation among the footballers. Socio-demographic variables (except region, level of participation, and age), did not present any significant relationship. Footballers who experienced stress and depression during the Covid-19 pandemic showed positive correlations between the two constructs. Athletes from India's Southern region perceived higher stress levels than those from the Western part of India. The level of participation and age had no significant effect on the participants' perceived stress and depression. � Copyright 2023: Publication Service of the University of Murcia, Murcia, Spain.
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    Exploring insights of hydroxychloroquine, a controversial drug in Covid-19: An update
    (Elsevier Ltd, 2021-03-18T00:00:00) Joshi, Gaurav; Thakur, Shikha; Mayank; Poduri, Ramarao
    The review summarizes chloroquine (CQ) and its safer derivative hydroxychloroquine (HCQ) and its utility in Covid-19. Recently this well-established drug made its way back to the headlines during the SARS-CoV-2 pandemic. This led to an upsurge in the scientific arena with multiple research and review articles along with expert opinions and commentaries. The HCQ has received mixed judgements so far about its efficacy to be used in Covid-19 patients in a limited trial conducted all across the Globe. The purpose of our article is to put forth the history, pharmacodynamics, and pharmacokinetics, along with the existing studies favouring and disapproving the role of HCQ in the treatment of Covid-19. We grouped HCQ use at three stages, this includes HCQ for i. prophylactic use by asymptomatic health workers or peoples at higher risk; ii. patients having mild symptoms; iii. patients with extreme symptoms. The review critically discusses the underlying plausible reasons and mechanisms exploring HCQ in prophylactic management or treatment of SARS-CoV-2. Furthermore, we have critically analysed the reported pharmacokinetic parameters and compiled the proponent, opponent, or neutral opinions on the use of HCQ in Covid-19. Authors discretion is to conduct more studies considering the optimal dosing regimen and pharmacokinetics assessment. � 2021 Elsevier Ltd
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    Recent efforts for drug identification from phytochemicals against SARS-CoV-2: Exploration of the chemical space to identify druggable leads
    (Elsevier Ltd, 2021-04-03T00:00:00) Joshi, Gaurav; Sindhu, Jayant; Thakur, Shikha; Rana, Abhilash; Sharma, Geetika; Mayank; Poduri, Ramarao
    Nature, which remains a central drug discovery pool, is always looked upon to find a putative druggable lead. The natural products and phytochemical derived from plants are essential during a global health crisis. This class represents one of the most practical and promising approaches to decrease pandemic's intensity owing to their therapeutic potential. The present manuscript is therefore kept forth to give the researchers updated information on undergoing research in allied areas of natural product-based drug discovery, particularly for Covid-19 disease. The study briefly shreds evidence from in vitro and in silico researches done so far to find a lead molecule against Covid-19. Following this, we exhaustively explored the concept of chemical space and molecular similarity parameters for the drug discovery about the lead(s) generated from in silico-based studies. The comparison was drawn using FDA-approved anti-infective agents during 2015�2020 using key descriptors to evaluate druglike properties. The outcomes of results were further corroborated using Molecular Dynamics studies which suggested the outcomes in alignment with chemical space ranking. In a nutshell, current research work aims to provide a holistic strategic approach to drug design, keeping in view the identified phytochemicals against Covid-19. � 2021 Elsevier Ltd
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    Exploring the magic bullets to identify Achilles� heel in SARS-CoV-2: Delving deeper into the sea of possible therapeutic options in Covid-19 disease: An update
    (Elsevier Ltd, 2020-11-27T00:00:00) Thakur, Shikha; Mayank; Sarkar, Bibekananda; Ansari, Arshad J.; Khandelwal, Akanksha; Arya, Anil; Poduri, Ramarao; Joshi, Gaurav
    The symptoms associated with Covid-19 caused by SARS-CoV-2 in severe conditions can cause multiple organ failure and fatality via a plethora of mechanisms, and it is essential to discover the efficacious and safe drug. For this, a successful strategy is to inhibit in different stages of the SARS-CoV-2 life cycle and host cell reactions. The current review briefly put forth the summary of the SARS-CoV-2 pandemic and highlight the critical areas of understanding in genomics, proteomics, medicinal chemistry, and natural products derived drug discovery. The review further extends to briefly put forth the updates in the drug testing system, biologics, biophysics, and their advances concerning SARS-CoV-2. The salient features include information on SARS-CoV-2 morphology, genomic characterization, and pathophysiology along with important protein targets and how they influence the drug design and development against SARS-CoV-2 and a concerted and integrated approach to target these stages. The review also gives the status of drug design and discovery to identify the drugs acting on critical targets in SARS-CoV-2 and host reactions to treat Covid-19. � 2020 Elsevier Ltd