School Of Basic And Applied Sciences

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    Impact of Covid-19 outbreak on stress and depression among Indian football players; [Impacto del brote de Covid-19 en el estr�s y la depresi�n de futbolistas indios]
    (Universidad de Murcia, 2023-06-13T00:00:00) Cherappurath, Nafih; Ahmed, Md. Dilsad; L�pez S�nchez, Guillermo F.; Begum, Shaheen; Sreelekha, N.; Elayaraja, M.; Rathnayaka, Anoma; Kabeer, Dilshith Azeezul
    The Coronavirus-19 (COVID-19) pandemic restricted our normal life activities for the past several months, continuing its impact. Its repercussions led many countries to remain locked down and closed institutions and workplaces. The closure severely impacted the sporting industry and hindered performing its normal activities. Sports and exercise are generally considered the best facilitator for embedding a healthy and active lifestyle and were not adequately advocated during the pandemic. This study aimed to examine the level of stress and depression among football players during the peak time of the Covid-19 outbreak. Furthermore, it measured whether the socio-demographic information, such as gender, region, and level of participation influenced participants' stress and depression during that time. A total of 204 football players recruited from different parts of India participated in this study. Participants� responses to stress and depression were measured through the Perceived Stress Scale (PSS) and the Patient Health Questionnaire (PHQ-9). Stress and depression showed a significant correlation among the footballers. Socio-demographic variables (except region, level of participation, and age), did not present any significant relationship. Footballers who experienced stress and depression during the Covid-19 pandemic showed positive correlations between the two constructs. Athletes from India's Southern region perceived higher stress levels than those from the Western part of India. The level of participation and age had no significant effect on the participants' perceived stress and depression. � Copyright 2023: Publication Service of the University of Murcia, Murcia, Spain.
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    Investigation of Indole-3-piperazinyl Derivatives as Potential Antidepressants: Design, Synthesis, In-Vitro, In-Vivo and In-Silico Analysis
    (John Wiley and Sons Inc, 2021-11-03T00:00:00) Kumar, Ravi R.; Kumar, Vijay; Kaur, Dilpreet; Nandi, Nilay K.; Dwivedi, Ashish R.; Kumar, Vinod; Kumar, Bhupinder
    Depression is declared the second leading cause of disability worldwide. Recently, cases of depression have increased significantly in adolescents, young adults as well as in elder population. Monoamine oxidase-A (MAO-A) is considered one of the major targets for the treatment of depression. In the current study, we have designed and synthesized various indole functionalized piperazinyl derivatives and evaluated them for in vitro MAO-A inhibitory activity and in vivo antidepressant-like activity. Most of the compounds were found to possess potent MAO-A inhibitory activity with IC50 values in the sub-micromolar range along with significant selectivity over MAO-B. Compounds RP1 and RP9 emerged as the most promising reversible MAO-A inhibitors with IC50 values of 0.11�0.03 ?M and 0.14�0.02 ?M and displayed selectivity of 193 folds and 178 folds over Monoamine oxidase-B (MAO-B), respectively. In the series, RP1 showed good intracellular ROS inhibitory activity along with neuroprotective properties. These compounds were found nontoxic against SH-SY5Y cells and explored antidepressant activities. In the in vivo Forced swimming test (FST) and Tail suspension test (TST) studies, RP1 exhibited potential antidepressant-like behavior similar to standard drug fluoxetine while compound RP9 showed antidepressant-like activity only in the TST studies. The molecular docking and dynamics studies further supported the results obtained in the in vitro and in vivo studies. Thus, the indole functionalized piperazinyl derivatives were found to be promising ligands and can be developed as new antidepressant molecules. � 2021 Wiley-VCH GmbH