School Of Basic And Applied Sciences

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Subject: search.filters.subject.Iron oxide nanoparticles

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    Potential of Iron Oxide Nanoparticles as Drug Delivery Vehicle
    (Springer Science and Business Media Deutschland GmbH, 2021-10-29T00:00:00) Hassan, Muhammad Aamir; Khan, Aqib Zafar; Sajid, Muhammad Munir; Javed, Yasir; Ullah, Asmat; Shad, Naveed Akhtar; Sharma, Surender K.; Shafique, Muhammad; Sarwar, Muhammad
    Nanotechnology has introduced new techniques and therapeutic approaches for the treatment of different cancer types. Current cancer-curing drugs have many limitations such as use of high concentrations, effects on other cells, and non-confinement at cancer sites, which reduce the efficacy of drugs and also induce toxic effects in other normal cells. Nanomaterials have provided new ways to increase the efficacy of already used cancer drugs by providing drug delivery systems. Anticancer drugs can be encapsulated/attached with the nanomaterials and delivered at specific sites and cells under certain microenvironment conditions. Among metallic oxide nanoparticles, iron-based particles have shown great potential in drug delivery and at the same time for cancer treatment by producing localized heat. Therefore, researchers have focused on iron oxide nanoparticles as drug delivery vehicles. This chapter highlights the synthesizing methods of iron oxide nanoparticles such as co-precipitation, thermal decomposition, microemulsion, sol�gel, and additional chemical methods including hydrothermal, sonochemical decomposition, and electrochemical for their wide range of biomedical applications. It also provides a brief overview of recent developments in iron oxide nanoparticles, some limitations in the explored research areas. and suggests future directions to overcome these limitations. � 2021, Springer Nature Switzerland AG.
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    Tuning the shape, size, phase composition and stoichiometry of iron oxide nanoparticles: The role of phosphate anions
    (Elsevier Ltd, 2020-09-17T00:00:00) Niraula, Gopal; Coaquira, Jose A.H.; Aragon, Fermin H.; Galeano Villar, Bianca M.; Mello, Alexandre; Garcia, Flavio; Muraca, Diego; Zoppellaro, Giorgio; Vargas, Jose M.; Sharma, Surender K.
    This work describes a microwave synthetic approach for the controlled assembly of ?-Fe2O3 nanosystems with defined morphologies, such as hollow nanotubes (NTs), solid nanorods (NRs) and nanodisks (NDs). The morphological control is aided during the crystallization processes by using phosphate anions as key surfactants in solution. Furthermore, the thermal reduction under H2 atmosphere of these NTs, NRs and NDs ?-Fe2O3 systems to the correspondent Fe3O4 nanomaterials preserved their initial morphologies. It was observed that the concentration of phosphate anions and volume of solvent had significant impact not only on controlling the shapes and sizes, but also phase composition and stoichiometry of the NTs, NRs and NDs nanoparticles. X-ray Rietveld refinement analysis of the NTs, NRs and NDs systems, after reduction in H2, revealed the presence of zero-valent iron (Fe0) in the final materials, with Fe0 fractions that decreased gradually in % from NTs (?16%), NRs (?11%) to NDs (?0%) upon increasing amount of phosphate anions. Bulk magnetic susceptibility measurements showed clear alterations of the Verwey transition temperatures (TV) and the development of unusual magnetic phenomena, such as magnetic vortex states in NDs, which was subsequently verified by micro-magnetic simulations. From the combination of XRD analysis, bulk magnetic susceptibility and M�ssbauer results, we provide herein a detailed mechanistic description of the chemical processes that gated the development of shape-controlled synthesis of NTs, NRs and NDs and give a detailed correlation between specific morphology and magneto-electronic behaviors. � 2020 Elsevier B.V.
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    Thiolated ?-cyclodextrin modified iron oxide nanoparticles for effective targeted cancer therapy
    (Elsevier Ltd, 2022-10-13T00:00:00) Nayak, Jyotsnamayee; Prajapati, Kumari Sunita; Kumar, Shashank; Vashistha, Vinod Kumar; Sahoo, Suban K.; Kumar, Rajender
    Inspired by the mitochondria iron-sulfur protein, direct functionalization of thiolated ?-cyclodextrin (?-CD-SH) on iron oxide nanoparticles (IONPs) through Fe-S bond was done. The resulting system had an average size of 14 nm with an ellipsoidal shape. The X-Ray photoelectron spectroscopy (XPS) confirmed the formation of the Fe-S bond. Doxorubicin (DOX) was chosen as a model drug, about 12.45 �M/mg entrapped in ?-CD-SH coated IONPs (T?CD-IONPs). The hybrid nanocarrier possessed high stability and drug loading efficiency. The invitro release data revealed an overall sustainable release profile without initial bust. The Higuchi kinetic model best fits the release mechanism, based on diffusion action in dosages proportional to the square root of time. The surface coating and particle size have a crucial role in the cellular responses and effective toxic mechanisms. The cellular internalization of drug-loaded nanoparticles (NPs) into the breast cancer cell line MCF-07 was done using MTT assay and confocal imaging. The prepared system shows high performance with an IC50 value at 67 nM of nanoparticle concentration. The prepared nanoparticles are promising candidates for the effective targeted delivery of hydrophobic drugs with enhanced theragnostic activity. � 2022 Elsevier Ltd