School Of Basic And Applied Sciences

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Subject: search.filters.subject.Pesticides

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    Potential environmental toxicant exposure, metabolizing gene variants and risk of PCOS-A systematic review
    (Elsevier Inc., 2021-06-11T00:00:00) Sharma, Priya; Bilkhiwal, Nisha; Chaturvedi, Pragya; Kumar, Sachin; Khetarpal, Preeti
    Exposure of environmental toxicants such as potentially toxic metals and pesticides have largely been attributed to produce adverse effects on general women's health and to be more precise on the reproductive system. In order to explore exposure of toxicants and metabolizing gene variants as risk factor for polycystic ovarian syndrome (PCOS), literature search was carried out using the databases PubMed, Central Cochrane Library, Google Scholar, Science Direct with appropriate keywords upto 6 December 2020. While most of the studies indicate higher serum Cu concentration and lower concentration of Mn as risk factor, studies also report presence of higher pesticide concentration in PCOS women. Genes such as MTHFR, CYPs participate in the metabolism of toxicants and may show different response due to underlying genetic variants. Thus, toxicant exposure are to some extent responsible for the pathogenesis of syndrome through oxidative stress and endocrine disruption, but the susceptibility may vary due to the underlying genetic polymorphism of the exposed population. � 2021 Elsevier Inc.
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    Global trends in pesticides: A looming threat and viable alternatives
    (Academic Press, 2020) Sharma, A; Shukla, A; Attri, K; Kumar, M; Kumar, P; Suttee, A; Singh, G; Barnwal, R.P; Singla, N.
    Pesticides are widely used chemical compounds in agriculture to destroy insects, pests and weeds. In modern era, they form an indispensable part of agricultural and health practices. Globally, nearly 3 billion kg of pesticides are used every year with a budget of ~40 billion USD. This extensive usage has increased the crop yield as well as led to significant reduction in harvest losses and thereby, enhanced food availability. On the other hand, indiscriminate usage of these chemicals has led to several environmental implications and caused adverse effects on human health. Epidemiological evidences have revealed the harmful effects of pesticides exposure on various organs including liver, brain, lungs and colon. Recent investigations have shown that pesticides can also lead to fatal consequences such as cancer among individuals. These chemicals enter ecosystem, thus hampering the sensitive environmental equilibrium through bio-accumulation. Due to their non-biodegradable nature, they can persist in nature for years and are regarded as potent biohazard. Worldwide, very few surveillance methods have been considered, which can bring awareness among the individuals, therefore the present review is an attempt to delineate consequences induced by various types of pesticide exposure on the environment. Further, the prospective of biopesticides use could facilitate the increase of crop production without compromising human health.- 2020 Elsevier Inc.
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    Investigation of combined genotoxic effect of pesticides on cancer cell lines
    (Central University of Punjab, 2013) Anju; Bhardwaj, Pankaj
    The use of pesticides in agriculture sector is increasing widely to alleviate crop loss due to pests. To combat problem of pest, various types of pesticides are widely used, out of which insecticide are majorly used. In Malwa region of Punjab lots of insecticides are used. These pesticides when present together they may result in combined response. This combined response can be of three types such as independent, dose addition and interaction (synergism or antagonism). This combined response is very big trouble, such as sometimes even low dose of pesticide which is not toxic individually can result in toxic response in the presence of another pesticide. In the present study, Malathion and Monocrotophos (widely used organophosphorous insecticides) selected for investigation of combined effect. Out of selected pesticide Malathion also detected in water, in present study. Various parameters for genotoxicity evaluation was carried out with exposure of pesticides on HCT-116 WT/ p53 mutant (colon cancer) cell lines. Results of present study suggested that combination of pesticides resulted in more cell death, oxidative stress, membrane instability and imbalanced antioxidative system. It is also evaluated that low dose exposure of pesticides individually and in combination resulted in increased cell survival, may be due to activation of defense mechanism with prior treatment. All parameters evaluated was with short term exposure of 1-2 days, so evaluated long term exposure of ten days and found that this resulted in very less cell number and changed cell morphology. It is observed that both pesticides showed genotoxicity individually as well as in combination. The combined exposure of both pesticides deviate from there expected effect for dose addition towards more toxicity. So it is concluded that there may be some interaction between these pesticides, which may be synergistic in nature, because observed more toxicity.