School Of Basic And Applied Sciences

Permanent URI for this communityhttps://kr.cup.edu.in/handle/32116/17

Browse

Subject: search.filters.subject.Resistant starch

Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    High resistant starch mutant wheat �TAC 35� reduced glycemia and ameliorated high fat diet induced metabolic dysregulation in mice
    (Academic Press, 2022-03-18T00:00:00) Rahim, Mohammed Saba; Kumar, Vibhu; Mishra, Ankita; Fandade, Vikas; Kumar, Vinay; Kiran kondepudi, Kanthi; Bishnoi, Mahendra; Roy, Joy
    Dietary supplementation of low glycemic index (GI) food obtained from cereal crops is affordable and can reduce the risk of developing diseases such as diabetes, coronary heart disease, obesity and colon cancer. In this study, two high resistant starch (HRS) wheat mutant lines (�TAC 35� and �TAC 28�) showed up to 25% drop in GI compared to parent wheat variety �C 306� in mice (P ? 0.001). Further, the best low GI mutant line, �TAC 35� was used to observe its health benefit effects against high fat diet (HFD) for 10-weeks in C57BL/6J mice model. The mutant showed a significant reduction in body weight and tissues (fat, liver, spleen) weight from ?23.5 to 68.4% with respect to HFD. It also showed significant increase in glucose tolerance (41%), insulin sensitivity (28%), liver SOD (26%), serum SOD (16.3%) and significant decrease in liver H2O2 (29%) and serum H2O2 (35%), LDL (39%) and total cholesterol (7%), pro-inflammatory markers: IL-6 (9.56%) and TNF? (23.32%). Furthermore, the HRS diet fostered a healthy bacterial population and resulted in a profound boost in butyrate (40%), lactate (23%), and acetate (28%). Besides, the HRS diet's preventative efficacy was also revealed by the expression of disease-related genes. This study emphasizes the critical health benefits of HRS-low GI wheat which may be promoted for obese and diabetic populations. � 2022 Elsevier Ltd
  • No Thumbnail Available
    Item
    High resistant starch mutant wheat �TAC 35� reduced glycemia and ameliorated high fat diet induced metabolic dysregulation in mice
    (Academic Press, 2022-03-18T00:00:00) Rahim, Mohammed Saba; Kumar, Vibhu; Mishra, Ankita; Fandade, Vikas; Kumar, Vinay; Kiran kondepudi, Kanthi; Bishnoi, Mahendra; Roy, Joy
    Dietary supplementation of low glycemic index (GI) food obtained from cereal crops is affordable and can reduce the risk of developing diseases such as diabetes, coronary heart disease, obesity and colon cancer. In this study, two high resistant starch (HRS) wheat mutant lines (�TAC 35� and �TAC 28�) showed up to 25% drop in GI compared to parent wheat variety �C 306� in mice (P ? 0.001). Further, the best low GI mutant line, �TAC 35� was used to observe its health benefit effects against high fat diet (HFD) for 10-weeks in C57BL/6J mice model. The mutant showed a significant reduction in body weight and tissues (fat, liver, spleen) weight from ?23.5 to 68.4% with respect to HFD. It also showed significant increase in glucose tolerance (41%), insulin sensitivity (28%), liver SOD (26%), serum SOD (16.3%) and significant decrease in liver H2O2 (29%) and serum H2O2 (35%), LDL (39%) and total cholesterol (7%), pro-inflammatory markers: IL-6 (9.56%) and TNF? (23.32%). Furthermore, the HRS diet fostered a healthy bacterial population and resulted in a profound boost in butyrate (40%), lactate (23%), and acetate (28%). Besides, the HRS diet's preventative efficacy was also revealed by the expression of disease-related genes. This study emphasizes the critical health benefits of HRS-low GI wheat which may be promoted for obese and diabetic populations. � 2022 Elsevier Ltd
  • Thumbnail Image
    Item
    Bioactive constituents in pulses and their health benefits
    (Springer India, 2017) Singh,Balwinder; Singh, Jatinder Pal; Shevkani, Khetan; Singh, Narpinder; Kaur, Amritpal
    Pulses are good sources of bioactive compounds such as polyphenols, phytosterols and non-digestible carbohydrates that play important physiological as well as metabolic roles. These compounds vary in concentration amongst different pulse species and varieties. Pulse seed coats are rich in water-insoluble fibres and polyphenols (having high antioxidant activities), while cotyledons contain higher soluble fibres, oligosaccharides, slowly digestible and resistant starch content. Ferulic acid is the most abundant phenolic acid present in pulses, while flavonol glycosides, anthocyanins and tannins are responsible for the seed coat colour. Sitosterol (most abundant), stigmasterol, and campesterol are the major phytosterols present in pulses. Pulse fibres, resistant starch and oligosaccharides function as probiotics and possess several other health benefits such as anti-inflammatory, anti-tumour, and reduce glucose as well as lipid levels. Beans and peas contain higher amounts of oligosaccharides than other pulses. Processing methods affect resistant starch, polyphenol composition and generally increase antioxidant activities of different pulses. In this review, the current information on pulse polyphenols, phytosterols, resistant starch, dietary fibre, oligosaccharides, antioxidant and associated health benefits are discussed. ? 2016, Association of Food Scientists & Technologists (India).