School Of Basic And Applied Sciences

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    Colistin Resistance and Management of Drug Resistant Infections
    (Hindawi Limited, 2022-12-10T00:00:00) Sharma, Juhi; Sharma, Divakar; Singh, Amit; Sunita, Kumari
    Colistin resistance is a globalized sensible issue because it has been considered a drug of the last-line resort to treat drug-resistant bacterial infections. The product of the mobilized colistin resistance (mcr) gene and its variants are the significant causes of colistin resistance, which is emerging due to the frequent colistin use in veterinary, and these genes circulate among the bacterial community. Apart from mcr genes, some other intrinsic genes and proteins are also involved in colistin resistance. Researchers focus on the most advanced genomics (whole genome sequencing), proteomics, and bioinformatics approaches to explore the question of colistin resistance. To combat colistin resistance, researchers developed various strategies such as the development of newer drugs, the repurposing of existing drugs, combinatorial treatment by colistin with other drugs, a nano-based approach, photodynamic therapy, a CRISPRi-based strategy, and a phage-based strategy. In this timeline review, we have discussed the development of colistin resistance and its management in developing countries. � 2022 Juhi Sharma et al.
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    Advances in the computational methods to understand protein folding and stability
    (Inderscience Publishers, 2022-11-09T00:00:00) Srikanth, Srimari; Srinivasan, Thamarai Selvi; Prabhu, Dhamodharan; Kadhirvel, Saraboji
    Understanding the molecular basis of life is important for advances in fundamental and applied biological research. Numerous and complex biological activities occur simultaneously in all living cells in a controlled manner to execute an optimal equilibrium and function. Specifically, life depends on the regular functioning of the protein molecules, which depends upon the attainment of the correct three-dimensional structure and its stability. Therefore, deducing a fundamental understanding of how proteins fold and stabilise in the native states is of great intellectual and technological significance. Similar to all natural events, protein folding is a physicochemical process that is much more complex in-vivo, with the association of chaperones and/or other co-factors. Perturbations in protein�s stability results in misfolded proteins and their aggregated forms associated with protein misfolding disorders. Interestingly, researchers are involved in developing computational methods to predict the folded state of the protein and its stabilising mechanisms, which are essential in designing biotechnologically and medicinally important protein molecules. The present review aims to explore developments in the computational procedures which aid in understanding protein folding and stability and its applications. Copyright � 2021 Inderscience Enterprises Ltd.
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    Colistin Resistance and Management of Drug Resistant Infections
    (Hindawi Limited, 2022-12-10T00:00:00) Sharma, Juhi; Sharma, Divakar; Singh, Amit; Sunita, Kumari
    Colistin resistance is a globalized sensible issue because it has been considered a drug of the last-line resort to treat drug-resistant bacterial infections. The product of the mobilized colistin resistance (mcr) gene and its variants are the significant causes of colistin resistance, which is emerging due to the frequent colistin use in veterinary, and these genes circulate among the bacterial community. Apart from mcr genes, some other intrinsic genes and proteins are also involved in colistin resistance. Researchers focus on the most advanced genomics (whole genome sequencing), proteomics, and bioinformatics approaches to explore the question of colistin resistance. To combat colistin resistance, researchers developed various strategies such as the development of newer drugs, the repurposing of existing drugs, combinatorial treatment by colistin with other drugs, a nano-based approach, photodynamic therapy, a CRISPRi-based strategy, and a phage-based strategy. In this timeline review, we have discussed the development of colistin resistance and its management in developing countries. � 2022 Juhi Sharma et al.