School Of Basic And Applied Sciences

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    Trisodium citrate dihydrate catalyzed one-pot pseudo four-component synthesis of fully functionalized pyridine derivatives
    (Taylor and Francis Ltd., 2022-07-22T00:00:00) Sharma, Aditi; Singh, Arvind; Priya, Anu; Kaur, Manmeet; Gupta, Vivek Kumar; Jaitak, Vikas; Banerjee, Bubun
    A facile and convenient method has been developed for the one-pot pseudo-four component synthesis of fully functionalized pyridine derivatives from the reactions of aromatic aldehydes, malononitrile and thiols in the presence of a catalytic amount of trisodium citrate dihydrate as an efficient metal-free catalyst in aqueous ethanol under refluxed conditions. All the reactions were completed within just 45 minutes and the desired products afforded in excellent yields (90�95%). Gram scale production of the desired compound was also achieved. Synthesis of biologically promising scaffolds, high atom economy, excellent yields, use of metal-free catalyst, less toxic solvents, no column chromatographic purifications, reusability of the solvent media, multiple carbon-carbon and carbon-heteroatom bond formations are some of the major advantages of this newly developed protocol. � 2022 Taylor & Francis Group, LLC.
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    Transition-Metal-Free Cascade C-N Bond Formation: An Effective Strategy for the Synthesis of ?-Carboline N-Fused Imidazolium Acetates and Estimation of their Light-Emitting Properties
    (Georg Thieme Verlag, 2023-08-08T00:00:00) Singh, Manpreet; Vaishali, Vaishali; Deepika, Deepika; Jyoti, Jyoti; Sharma, Shubham; Banyal, Naveen; Kumar, Prashant; Budhalakoti, Bharti; Malakar, Chandi C.; Singh, Virender
    A simple, efficient, and practical metal-free protocol has been devised to synthesize imidazopyrido[3,4-b]indole-based fluorophores decorated with carbazole/ F-carboline/pyridine scaffolds via three consecutive C.N bond formations in a single operation. A wide range of aromatic amines (2-aminopyridines, 3-aminocarbazole, and anilines) were successfully applied to synthesize the complex imidazolium ions. The significant features of this strategy include high efficiency, mild and environmentally benign reaction conditions, no chromatographic purification, and broad substrate scope with excellent yields of the isolated products. Moreover, excellent photophysical properties (up to 85%) were exhibited by these fluorophores. � 2022 Georg Thieme Verlag. All rights reserved.